β-Amyloid neurotoxicity

Research output: Contribution to journalArticlepeer-review

Abstract

β-amyloid (βA, 39-43 amino acids) deposition in brain parenchyma and vessel walls is a major pathological feature of Alzheimer's disease (AD). This is associated with degenerative changes of neuronal cell bodies and processes, and neuronal death. βA, a portion of a larger transmembrane glycoprotein, has been reported to be toxic in several tissue culture models. The neurotoxic activity of βA synthetic peptides is associated with their fibrillogenic capacity. However, in vivo studies on βA neurotoxic activity have not proved conclusive and further investigations are necessary to establish the pathogenetic role of βA in AD.

Original languageEnglish
Pages (from-to)211-225
Number of pages15
JournalFunctional Neurology
Volume8
Issue number3
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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