β-blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: A meta-analysis

Marco Senzolo, Evangelos Cholongitas, Patrizia Burra, Gioacchino Leandro, Ulrich Thalheimer, David Patch, Andrew Kenneth Burroughs

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Bacterial infections have been hypothetized to be a trigger of variceal bleeding in cirrhotic patients and b-blockers may have a protective effect by decreasing bacterial translocation, reducing portal pressure. The aim of our study was to evaluate the possible role of b-blockers in preventing spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis and ascites. Materials and Methods: Extensive search of the literature including randomized controlled trial (RCT) and non-RCT of primary and secondary prophylaxis for variceal bleeding in cirrhotics using β-blockers were evaluated. We performed a meta-analysis using the occurrence of SBP as endpoint in all the studies, using the random effect model. Results: Three RCT and three retrospective studies in which b-blockers were evaluated against no treatment for the prevention of SBP in ascitic cirrhotics were included. There was a statistically significant difference of 12.1%, P

Original languageEnglish
Pages (from-to)1189-1193
Number of pages5
JournalLiver International
Volume29
Issue number8
DOIs
Publication statusPublished - 2009

Keywords

  • Cirrhosis
  • Non selective beta blockers
  • Spontanous Bacterial peritonitis

ASJC Scopus subject areas

  • Hepatology
  • Medicine(all)

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