β-cell transplantation in diabetes mellitus

S. Pellegrini, V. Sordi, L. Piemonti

Research output: Contribution to journalArticle

Abstract

Patients with diabetes mellitus suffer either from destruction of pancreatic β-cells or progressive deterioration of their function. Thus, transplantation of an intact β-cell population fully capable of insulin secretion is the only means to cure this disease. Despite glycemic benefits and decrease in risks for late complications, islet transplantation or complete pancreatic grafting in humans remains a challenge due to necessity of lifetime immunosuppression and increasingly sparse donor resources. Current paper presents a review of modern endeavours to obtain a limitless source for glucose-sensitive insulin secreting cells. We discuss, in particular, complex aspects of β-cell proliferation and/or neogenesis in vivo, issues with xenogenous pancreatic islets, and latest advances in controlled differentiation of embryonic and induced polypotent stem cells - the most promising and relevant source of β-cells.

Original languageEnglish
Pages (from-to)11-20
Number of pages10
JournalDiabetes Mellitus
Issue number3
DOIs
Publication statusPublished - 2013

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Keywords

  • Diabetes mellirus
  • Pancreatic β-cells
  • Proliferation
  • Stem cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

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