β-endorphin cerebrospinal fluid decrease in untreated parkinsonian patients

Giuseppe Nappi, Felice Petraglia, Emilia Martignoni, Fabio Facchinetti, Giorgio Bono, Andrea R. Genazzani

Research output: Contribution to journalArticle

Abstract

We measured CSF and plasma contents of β-endorphin (β-EP), β-lipotropin (β-LPH), and ACTH in 24 patients with Parkinson’s disease; 14 had not been treated. CSF β-EP concentrations in untreated patients were lower than in 15 controls (P <0.005), but values did not differ significantly in treated and untreated patients. In untreated and treated patients, ACTH and β-LPH CSF, and β-EP, β-LPH, and ACTH plasma concentrations were in the same range as controls. The Parkinson’s disease-related decrease of CSF β-EP levels further supports the concept that there is a generalized brain disorder in Parkinson’s disease affecting more than dopaminergic neurons in the substantia nigra.

Original languageEnglish
Pages (from-to)1371-1374
Number of pages4
JournalNeurology
Volume35
Issue number9
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

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    Nappi, G., Petraglia, F., Martignoni, E., Facchinetti, F., Bono, G., & Genazzani, A. R. (1985). β-endorphin cerebrospinal fluid decrease in untreated parkinsonian patients. Neurology, 35(9), 1371-1374.