β Endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis

M. Gironi, R. Furlan, M. Rovaris, G. Comi, M. Filippi, A. E. Panerai, P. Sacerdote

Research output: Contribution to journalArticle

Abstract

The possible link between the opioid peptide β endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of β endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest β endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest n patients with the progressive forms. Average β endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that β endorphin may have a role in the downregulation of the inflammatory process.

Original languageEnglish
Pages (from-to)495-497
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume74
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

Fingerprint

Endorphins
Multiple Sclerosis
Blood Cells
Phenotype
Magnetic Resonance Imaging
Relapsing-Remitting Multiple Sclerosis
Opioid Peptides
Down-Regulation
Brain

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

β Endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis. / Gironi, M.; Furlan, R.; Rovaris, M.; Comi, G.; Filippi, M.; Panerai, A. E.; Sacerdote, P.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 74, No. 4, 01.04.2003, p. 495-497.

Research output: Contribution to journalArticle

@article{984b26dae4e241bc9dff2ed6cee8df7b,
title = "β Endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis",
abstract = "The possible link between the opioid peptide β endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of β endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest β endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest n patients with the progressive forms. Average β endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that β endorphin may have a role in the downregulation of the inflammatory process.",
author = "M. Gironi and R. Furlan and M. Rovaris and G. Comi and M. Filippi and Panerai, {A. E.} and P. Sacerdote",
year = "2003",
month = "4",
day = "1",
doi = "10.1136/jnnp.74.4.495",
language = "English",
volume = "74",
pages = "495--497",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "4",

}

TY - JOUR

T1 - β Endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis

AU - Gironi, M.

AU - Furlan, R.

AU - Rovaris, M.

AU - Comi, G.

AU - Filippi, M.

AU - Panerai, A. E.

AU - Sacerdote, P.

PY - 2003/4/1

Y1 - 2003/4/1

N2 - The possible link between the opioid peptide β endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of β endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest β endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest n patients with the progressive forms. Average β endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that β endorphin may have a role in the downregulation of the inflammatory process.

AB - The possible link between the opioid peptide β endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of β endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest β endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest n patients with the progressive forms. Average β endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that β endorphin may have a role in the downregulation of the inflammatory process.

UR - http://www.scopus.com/inward/record.url?scp=0037380930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037380930&partnerID=8YFLogxK

U2 - 10.1136/jnnp.74.4.495

DO - 10.1136/jnnp.74.4.495

M3 - Article

C2 - 12640071

AN - SCOPUS:0037380930

VL - 74

SP - 495

EP - 497

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 4

ER -