β Endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis

M. Gironi, R. Furlan, M. Rovaris, G. Comi, M. Filippi, A. E. Panerai, P. Sacerdote

Research output: Contribution to journalArticlepeer-review

Abstract

The possible link between the opioid peptide β endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of β endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest β endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest n patients with the progressive forms. Average β endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that β endorphin may have a role in the downregulation of the inflammatory process.

Original languageEnglish
Pages (from-to)495-497
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume74
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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