Interactions between HPA (Hypothalamic-pituitary-axis) and immune system seem to involve the EPO (endogenous opioid peptides) system, as shown by some recent findings. Possible relationships between β-endorphin (β-End) synthesis and severity rate of immunodeficiency have been studied in 48 HIV Ab positive patients, at different stages of infection. A statistically significant decrease in the β-End synthesis was observed in these patients, as compared to a control group of 19 healthy subjects, but this decrease was not related to the CD4+ T lymphocytes number. Plasmatic levels modifications of HPA-related peptides were not observed in the IVC1 CDC group.
|Number of pages||5|
|Journal||European Review for Medical and Pharmacological Sciences|
|Publication status||Published - 1995|
- endogenous opioid peptides system
- HIV infection
- hypothalamic-pituitary-adrenocorticosurrenalic axis
ASJC Scopus subject areas