β-endorphins ACTH and cortisol in CSF and plasma of HIV infected patients

F. Spinazzola, C. Barletta, G. Demartino, F. Martini, S. Natili, P. Noto, F. Ferri, G. Tossini, G. Visco

Research output: Contribution to journalArticle

Abstract

Interactions between HPA (Hypothalamic-pituitary-axis) and immune system seem to involve the EPO (endogenous opioid peptides) system, as shown by some recent findings. Possible relationships between β-endorphin (β-End) synthesis and severity rate of immunodeficiency have been studied in 48 HIV Ab positive patients, at different stages of infection. A statistically significant decrease in the β-End synthesis was observed in these patients, as compared to a control group of 19 healthy subjects, but this decrease was not related to the CD4+ T lymphocytes number. Plasmatic levels modifications of HPA-related peptides were not observed in the IVC1 CDC group.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalEuropean Review for Medical and Pharmacological Sciences
Volume17
Issue number5
Publication statusPublished - 1995

Keywords

  • β-endorphin
  • endogenous opioid peptides system
  • HIV infection
  • hypothalamic-pituitary-adrenocorticosurrenalic axis

ASJC Scopus subject areas

  • Pharmacology

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    Spinazzola, F., Barletta, C., Demartino, G., Martini, F., Natili, S., Noto, P., Ferri, F., Tossini, G., & Visco, G. (1995). β-endorphins ACTH and cortisol in CSF and plasma of HIV infected patients. European Review for Medical and Pharmacological Sciences, 17(5), 161-165.