β-Galactosidase from Aspergillus niger in adult lactose malabsorption: A double-blind crossover study

G. R. Corazza, G. Benati, M. Sorge, A. Strocchi, G. Calza, G. Gasbarrini

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

An assessment was made of the efficacy of a β-galactosidase, obtained from Aspergillus niger and added to intact milk, in decreasing lactose malabsorption and intolerance. Sixteen adult patients with malabsorption and intolerance to this sugar were studied in a double-blind crossover study vs. placebo. A 5-hour hydrogen breath test was used to assess malabsorption of lactose contained in 400 ml milk. When compared with placebo, the addition of exogenous lactase to intact milk caused a statistically significant reduction in the maximum breath H 2 concentration (P <0.01) and in the cumulative H 2 excretion (P <0.005). In the same way, the cumulative index for gastrointestinal intolerance was significantly lower (P <0.005) after the ingestion of lactase-added milk. This study demonstrates that enzyme replacement therapy, with β-galactosidases obtained from Aspergillus niger, is effective in decreasing lactose malabsorption and its consequent intolerance in adult subjects with lactase deficiency.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalAlimentary Pharmacology and Therapeutics
Volume6
Issue number1
Publication statusPublished - 1992

Fingerprint

Galactosidases
Lactose Intolerance
Aspergillus niger
Lactase
Double-Blind Method
Cross-Over Studies
Milk
Placebos
Enzyme Replacement Therapy
Breath Tests
Hydrogen
Eating

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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β-Galactosidase from Aspergillus niger in adult lactose malabsorption : A double-blind crossover study. / Corazza, G. R.; Benati, G.; Sorge, M.; Strocchi, A.; Calza, G.; Gasbarrini, G.

In: Alimentary Pharmacology and Therapeutics, Vol. 6, No. 1, 1992, p. 61-66.

Research output: Contribution to journalArticle

Corazza, G. R. ; Benati, G. ; Sorge, M. ; Strocchi, A. ; Calza, G. ; Gasbarrini, G. / β-Galactosidase from Aspergillus niger in adult lactose malabsorption : A double-blind crossover study. In: Alimentary Pharmacology and Therapeutics. 1992 ; Vol. 6, No. 1. pp. 61-66.
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