β2-Adrenergic Receptor Gene Polymorphisms and Risk of Ischemic Stroke

Rosita Stanzione, Emanuele Di Angelantonio, Anna Evangelista, Daniela Barbato, Simona Marchitti, Bastianina Zanda, Angelo Pirisi, Giovanni Quarta, Massimo Volpe, Speranza Rubattu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: β2-adrenergic receptors (β2-AR) mediate vasorelaxation in response to adrenergic agents. Genetic polymorphisms of β2-AR were implicated in various cardiovascular and noncardiovascular traits. Methods: We tested the role of the β2AR-16 and β2AR-27 gene variants in the susceptibility to the development of ischemic stroke in a genetically homogenous and clinically well-characterized case-control sample that included 294 cases and 286 controls from Sardinia, Italy. This population was shown to be an optimal study sample for carrying out genetic analyses. Results: Age, hypertension, dyslipidemia, and atrial fibrillation were independent risk factors for stroke in this cohort. We found that the presence of the Glu27 allelic variant was associated with a significantly increased risk of stroke when assuming a recessive mode of inheritance (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.17-2.41; P = .005). The same results were obtained for the subgroup of ischemic strokes of arterial origin (n = 215): OR, 1.71; 95% CI, 1.14-2.57; P = .009. Furthermore, haplotype analysis confirmed that the presence of the Glu27 allele increased the risk of cerebrovascular accidents. Conclusions: Our data suggest that the Glu27 allelic variant of the β2-AR gene may be a determinant of ischemic stroke.

Original languageEnglish
Pages (from-to)657-662
Number of pages6
JournalAmerican Journal of Hypertension
Volume20
Issue number6
DOIs
Publication statusPublished - Jun 2007

Keywords

  • β2-adrenergic receptor
  • genetics
  • ischemic stroke
  • polymorphisms

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'β2-Adrenergic Receptor Gene Polymorphisms and Risk of Ischemic Stroke'. Together they form a unique fingerprint.

Cite this