γδ T cell receptor-bearing lymphocytes during Epstein-Barr virus infection

Paolo De Paoli, Daniele Gennari, Paola Martelli, Vittorio Cavarzerani, Roberto Comoretto, Gianfranco Santini

Research output: Contribution to journalArticle

Abstract

Lymphocytes bearing γδ T cell receptors (TCR) constitute a minor subpopulation of human peripheral blood lymphocytes. Their role and function during microbial infections are largely unknown. In 10 patients with Epstein-Barr virus-induced infectious mononucleosis, the γδ TCR-expressing T cell population expanded during the acute phase. These cells were largely δTCS1-, CD4-, and CD8- but expressed activation antigens such as human leukocyte antigen-DR and CD38. The convalescent phase of infectious mononucleosis was characterized by a relative persistence of γδ T cells. Together these data suggest a possible role of γδ cells in the control of primary Epstein-Barr virus infection in humans.

Original languageEnglish
Pages (from-to)1013-1016
Number of pages4
JournalJournal of Infectious Diseases
Volume161
Issue number5
Publication statusPublished - May 1990

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    De Paoli, P., Gennari, D., Martelli, P., Cavarzerani, V., Comoretto, R., & Santini, G. (1990). γδ T cell receptor-bearing lymphocytes during Epstein-Barr virus infection. Journal of Infectious Diseases, 161(5), 1013-1016.