γδ T cells as a potential tool in colon cancer immunotherapy

Thiranut Ramutton; Simona Buccheri; Francesco Dieli; Matilde Todaro; Giorgio Stassi; Serena Meraviglia

doi:10.2217/imt.14.59

γδ T cells as a potential tool in colon cancer immunotherapy

Thiranut Ramutton, Simona Buccheri, Francesco Dieli, Matilde Todaro, Giorgio Stassi, Serena Meraviglia

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Research output: Contribution to journal › Article › peer-review

Abstract

γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the design of novel and highly innovative immunotherapy in patients with colon cancer.

Original language	English
Pages (from-to)	989-999
Number of pages	11
Journal	Immunotherapy
Volume	6
Issue number	9
DOIs	https://doi.org/10.2217/imt.14.59
Publication status	Published - Sep 1 2014

Keywords

colon cancer
HDAC inhibitor
immune surveillance
immunotherapy
MICA/B
NKG2D-mediated killing
Vγ9Vγ2 T cells

ASJC Scopus subject areas

Immunology and Allergy
Oncology
Immunology
Medicine(all)

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title = "γδ T cells as a potential tool in colon cancer immunotherapy",

abstract = "γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the design of novel and highly innovative immunotherapy in patients with colon cancer.",

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AU - Ramutton, Thiranut

AU - Buccheri, Simona

AU - Dieli, Francesco

AU - Todaro, Matilde

AU - Stassi, Giorgio

AU - Meraviglia, Serena

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