γδ T cells as a potential tool in colon cancer immunotherapy

Thiranut Ramutton, Simona Buccheri, Francesco Dieli, Matilde Todaro, Giorgio Stassi, Serena Meraviglia

Research output: Contribution to journalArticle

Abstract

γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the design of novel and highly innovative immunotherapy in patients with colon cancer.

Original languageEnglish
Pages (from-to)989-999
Number of pages11
JournalImmunotherapy
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 1 2014

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Keywords

  • colon cancer
  • HDAC inhibitor
  • immune surveillance
  • immunotherapy
  • MICA/B
  • NKG2D-mediated killing
  • Vγ9Vγ2 T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology
  • Medicine(all)

Cite this

Ramutton, T., Buccheri, S., Dieli, F., Todaro, M., Stassi, G., & Meraviglia, S. (2014). γδ T cells as a potential tool in colon cancer immunotherapy. Immunotherapy, 6(9), 989-999. https://doi.org/10.2217/imt.14.59