γ Chain composition in five Italian newborns heterozygous for Hb F malta Gγ117His→Arg

U. Mazza, T. Meloni, O. David, P. G. Pich, C. Camaschella, G. Saglio, M. A. Ciocca Vasino, A. Guerrasio, G. Ricco

Research output: Contribution to journalArticlepeer-review

Abstract

The percentage of Hb F Malta Gγ117His→Arg and the γ chain composition have been evaluated at birth and at different times after birth in five Italian newborns heterozygous for this variant. The percentage of Hb F Malta ranged at birth from 24% to 31% of the total Hb F, while the average Gγ/Aγ chain ratio was about 7/3, overlapping the values observed in normal newborns. Tγ chains were detected in three out of five newborns, with a percentage of about 10% of the total Hb F. After birth the Hb F Malta declined faster than the total Hb F; thus, the Hb F decrease during the first 45 d of life is mainly due to the switch-off of the Gγ lucus containing the Hb F Malta gene.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalBritish Journal of Haematology
Volume44
Issue number1
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Hematology

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