TY - JOUR
T1 - γ Chain composition in five Italian newborns heterozygous for Hb F malta Gγ117His→Arg
AU - Mazza, U.
AU - Meloni, T.
AU - David, O.
AU - Pich, P. G.
AU - Camaschella, C.
AU - Saglio, G.
AU - Ciocca Vasino, M. A.
AU - Guerrasio, A.
AU - Ricco, G.
PY - 1980
Y1 - 1980
N2 - The percentage of Hb F Malta Gγ117His→Arg and the γ chain composition have been evaluated at birth and at different times after birth in five Italian newborns heterozygous for this variant. The percentage of Hb F Malta ranged at birth from 24% to 31% of the total Hb F, while the average Gγ/Aγ chain ratio was about 7/3, overlapping the values observed in normal newborns. Tγ chains were detected in three out of five newborns, with a percentage of about 10% of the total Hb F. After birth the Hb F Malta declined faster than the total Hb F; thus, the Hb F decrease during the first 45 d of life is mainly due to the switch-off of the Gγ lucus containing the Hb F Malta gene.
AB - The percentage of Hb F Malta Gγ117His→Arg and the γ chain composition have been evaluated at birth and at different times after birth in five Italian newborns heterozygous for this variant. The percentage of Hb F Malta ranged at birth from 24% to 31% of the total Hb F, while the average Gγ/Aγ chain ratio was about 7/3, overlapping the values observed in normal newborns. Tγ chains were detected in three out of five newborns, with a percentage of about 10% of the total Hb F. After birth the Hb F Malta declined faster than the total Hb F; thus, the Hb F decrease during the first 45 d of life is mainly due to the switch-off of the Gγ lucus containing the Hb F Malta gene.
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M3 - Article
C2 - 6155133
AN - SCOPUS:0018840209
VL - 44
SP - 93
EP - 99
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -