γ Chain composition in five Italian newborns heterozygous for Hb F malta Gγ117His→Arg

U. Mazza, T. Meloni, O. David, P. G. Pich, C. Camaschella, G. Saglio, M. A. Ciocca Vasino, A. Guerrasio, G. Ricco

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The percentage of Hb F Malta Gγ117His→Arg and the γ chain composition have been evaluated at birth and at different times after birth in five Italian newborns heterozygous for this variant. The percentage of Hb F Malta ranged at birth from 24% to 31% of the total Hb F, while the average Gγ/Aγ chain ratio was about 7/3, overlapping the values observed in normal newborns. Tγ chains were detected in three out of five newborns, with a percentage of about 10% of the total Hb F. After birth the Hb F Malta declined faster than the total Hb F; thus, the Hb F decrease during the first 45 d of life is mainly due to the switch-off of the Gγ lucus containing the Hb F Malta gene.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalBritish Journal of Haematology
Volume44
Issue number1
Publication statusPublished - 1980

Fingerprint

Malta
Parturition
Genes

ASJC Scopus subject areas

  • Hematology

Cite this

Mazza, U., Meloni, T., David, O., Pich, P. G., Camaschella, C., Saglio, G., ... Ricco, G. (1980). γ Chain composition in five Italian newborns heterozygous for Hb F malta Gγ117His→Arg. British Journal of Haematology, 44(1), 93-99.

γ Chain composition in five Italian newborns heterozygous for Hb F malta Gγ117His→Arg. / Mazza, U.; Meloni, T.; David, O.; Pich, P. G.; Camaschella, C.; Saglio, G.; Ciocca Vasino, M. A.; Guerrasio, A.; Ricco, G.

In: British Journal of Haematology, Vol. 44, No. 1, 1980, p. 93-99.

Research output: Contribution to journalArticle

Mazza, U, Meloni, T, David, O, Pich, PG, Camaschella, C, Saglio, G, Ciocca Vasino, MA, Guerrasio, A & Ricco, G 1980, 'γ Chain composition in five Italian newborns heterozygous for Hb F malta Gγ117His→Arg', British Journal of Haematology, vol. 44, no. 1, pp. 93-99.
Mazza, U. ; Meloni, T. ; David, O. ; Pich, P. G. ; Camaschella, C. ; Saglio, G. ; Ciocca Vasino, M. A. ; Guerrasio, A. ; Ricco, G. / γ Chain composition in five Italian newborns heterozygous for Hb F malta Gγ117His→Arg. In: British Journal of Haematology. 1980 ; Vol. 44, No. 1. pp. 93-99.
@article{398147b297414f3bad7b963735977a98,
title = "γ Chain composition in five Italian newborns heterozygous for Hb F malta Gγ117His→Arg",
abstract = "The percentage of Hb F Malta Gγ117His→Arg and the γ chain composition have been evaluated at birth and at different times after birth in five Italian newborns heterozygous for this variant. The percentage of Hb F Malta ranged at birth from 24{\%} to 31{\%} of the total Hb F, while the average Gγ/Aγ chain ratio was about 7/3, overlapping the values observed in normal newborns. Tγ chains were detected in three out of five newborns, with a percentage of about 10{\%} of the total Hb F. After birth the Hb F Malta declined faster than the total Hb F; thus, the Hb F decrease during the first 45 d of life is mainly due to the switch-off of the Gγ lucus containing the Hb F Malta gene.",
author = "U. Mazza and T. Meloni and O. David and Pich, {P. G.} and C. Camaschella and G. Saglio and {Ciocca Vasino}, {M. A.} and A. Guerrasio and G. Ricco",
year = "1980",
language = "English",
volume = "44",
pages = "93--99",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "1",

}

TY - JOUR

T1 - γ Chain composition in five Italian newborns heterozygous for Hb F malta Gγ117His→Arg

AU - Mazza, U.

AU - Meloni, T.

AU - David, O.

AU - Pich, P. G.

AU - Camaschella, C.

AU - Saglio, G.

AU - Ciocca Vasino, M. A.

AU - Guerrasio, A.

AU - Ricco, G.

PY - 1980

Y1 - 1980

N2 - The percentage of Hb F Malta Gγ117His→Arg and the γ chain composition have been evaluated at birth and at different times after birth in five Italian newborns heterozygous for this variant. The percentage of Hb F Malta ranged at birth from 24% to 31% of the total Hb F, while the average Gγ/Aγ chain ratio was about 7/3, overlapping the values observed in normal newborns. Tγ chains were detected in three out of five newborns, with a percentage of about 10% of the total Hb F. After birth the Hb F Malta declined faster than the total Hb F; thus, the Hb F decrease during the first 45 d of life is mainly due to the switch-off of the Gγ lucus containing the Hb F Malta gene.

AB - The percentage of Hb F Malta Gγ117His→Arg and the γ chain composition have been evaluated at birth and at different times after birth in five Italian newborns heterozygous for this variant. The percentage of Hb F Malta ranged at birth from 24% to 31% of the total Hb F, while the average Gγ/Aγ chain ratio was about 7/3, overlapping the values observed in normal newborns. Tγ chains were detected in three out of five newborns, with a percentage of about 10% of the total Hb F. After birth the Hb F Malta declined faster than the total Hb F; thus, the Hb F decrease during the first 45 d of life is mainly due to the switch-off of the Gγ lucus containing the Hb F Malta gene.

UR - http://www.scopus.com/inward/record.url?scp=0018840209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018840209&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 93

EP - 99

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 1

ER -