γ-Hydroxybutyric acid-induced psychosis and seizures

Annachiara Cagnin, Sara Pompanin, Valeria Manfioli, Chiara Briani, Alberto Zambon, Marina Saladini, Mauro Dam

Research output: Contribution to journalArticlepeer-review

Abstract

Disulfiram and γ-hydroxybutyric acid (GHB) are used to treat alcohol dependence and may both increase dopamine brain levels and modulate GABAergic transmission. We describe a patient affected by bipolar disorder (on valproate as mood-stabilizing treatment) and alcohol dependence who developed a disulfiram-induced hypomanic episode and in whom the switch from disulfiram to GHB induced recurrent convulsive seizures, not responsive to treatment with diazepam, and psychosis. Seizures and psychiatric symptoms ceased after GHB discontinuation. We outline the deregulation of the neurotransmitter systems (GABAergic and dopaminergic networks) that are involved in these drug-drug interactions and that might be responsible for both psychosis and generalized tonic-clonic seizures resistant to standard treatments.

Original languageEnglish
Pages (from-to)203-205
Number of pages3
JournalEpilepsy and Behavior
Volume21
Issue number2
DOIs
Publication statusPublished - Jun 2011

Keywords

  • γ-hydroxybutyric acid
  • Alcohol dependence
  • Disulfiram
  • Psychosis
  • Seizures
  • Succinic semialdehyde dehydrogenase
  • Valproate

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

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