ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment

Veronica Gatti, Claudia Fierro, Margherita Annicchiarico-Petruzzelli, Angelo Peschiaroli, Gerry Melino

Research output: Contribution to journalReview article

Abstract

Squamous cell carcinoma (SCC) is a treatment-refractory tumour which arises from the epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin. Accumulating evidence has revealed a number of genomic, clinical and molecular features commonly observed in SCC of distinct origins. Some of these genetic events culminate in fostering the activity of ΔNp63, a potent oncogene which exerts its pro-tumourigenic effects by regulating specific transcriptional programmes to sustain malignant cell proliferation and survival. In this review, we will describe the genetic and epigenetic determinants underlying ΔNp63 oncogenic activities in SCC, and discuss some relevant transcriptional effectors of ΔNp63, emphasizing their impact in modulating the crosstalk between tumour cells and tumour microenvironment (TME).

Original languageEnglish
Pages (from-to)981-1001
Number of pages21
JournalMolecular Oncology
Volume13
Issue number5
DOIs
Publication statusPublished - May 2019

Keywords

  • p63
  • squamous cell carcinoma
  • transcription factor
  • tumour microenvironment

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Oncology
  • Cancer Research

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