TY - JOUR
T1 - ΔNp63 in squamous cell carcinoma
T2 - defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment
AU - Gatti, Veronica
AU - Fierro, Claudia
AU - Annicchiarico-Petruzzelli, Margherita
AU - Peschiaroli, Angelo
AU - Melino, Gerry
PY - 2019/5
Y1 - 2019/5
N2 - Squamous cell carcinoma (SCC) is a treatment-refractory tumour which arises from the epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin. Accumulating evidence has revealed a number of genomic, clinical and molecular features commonly observed in SCC of distinct origins. Some of these genetic events culminate in fostering the activity of ΔNp63, a potent oncogene which exerts its pro-tumourigenic effects by regulating specific transcriptional programmes to sustain malignant cell proliferation and survival. In this review, we will describe the genetic and epigenetic determinants underlying ΔNp63 oncogenic activities in SCC, and discuss some relevant transcriptional effectors of ΔNp63, emphasizing their impact in modulating the crosstalk between tumour cells and tumour microenvironment (TME).
AB - Squamous cell carcinoma (SCC) is a treatment-refractory tumour which arises from the epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin. Accumulating evidence has revealed a number of genomic, clinical and molecular features commonly observed in SCC of distinct origins. Some of these genetic events culminate in fostering the activity of ΔNp63, a potent oncogene which exerts its pro-tumourigenic effects by regulating specific transcriptional programmes to sustain malignant cell proliferation and survival. In this review, we will describe the genetic and epigenetic determinants underlying ΔNp63 oncogenic activities in SCC, and discuss some relevant transcriptional effectors of ΔNp63, emphasizing their impact in modulating the crosstalk between tumour cells and tumour microenvironment (TME).
KW - p63
KW - squamous cell carcinoma
KW - transcription factor
KW - tumour microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85063257129&partnerID=8YFLogxK
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U2 - 10.1002/1878-0261.12473
DO - 10.1002/1878-0261.12473
M3 - Review article
C2 - 30845357
AN - SCOPUS:85063257129
VL - 13
SP - 981
EP - 1001
JO - Molecular Oncology
JF - Molecular Oncology
SN - 1574-7891
IS - 5
ER -