ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells

Veronica Gatti, Claudia Fierro, Mirco Compagnone, Federica Giangrazi, Elke Katrin Markert, Lucilla Bongiorno-Borbone, Gerry Melino, Angelo Peschiaroli

Research output: Contribution to journalArticle

Abstract

Triple negative breast cancers (TNBC) represent the most aggressive and clinically relevant breast carcinomas. On the basis of specific molecular signature, the majority of TNBC can be classified as basal-like breast carcinoma. Here, we report data showing that in basal-like breast carcinoma cells ΔNp63 is capable of sustaining the production of the hyaluronic acid (HA), one of the major component of the extracellular matrix (ECM). At molecular level, we found that ΔNp63 regulates the expression of HA-related genes, such as the HA synthase HAS3, the hyaluronidase HYAL-1 and CD44, the major HA cell membrane receptor. By controlling this pathway, ∆Np63 contributes to maintain the self-renewal of breast cancer stem cells. Importantly, high HAS3 expression is a negative prognostic factor of TNBC patients. Our data suggest that in basal-type breast carcinoma ∆Np63 might favor a HA-rich microenviroment, which can sustain tumor proliferation and stemness.

Original languageEnglish
Pages (from-to)65
Number of pages9
JournalOncogenesis
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 24 2018

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Hyaluronic Acid
Triple Negative Breast Neoplasms
Breast Neoplasms
Genes
Hyaluronoglucosaminidase
Neoplastic Stem Cells
Extracellular Matrix
Cell Membrane
Neoplasms

Cite this

Gatti, V., Fierro, C., Compagnone, M., Giangrazi, F., Markert, E. K., Bongiorno-Borbone, L., ... Peschiaroli, A. (2018). ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells. Oncogenesis, 7(8), 65. https://doi.org/10.1038/s41389-018-0073-3

ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells. / Gatti, Veronica; Fierro, Claudia; Compagnone, Mirco; Giangrazi, Federica; Markert, Elke Katrin; Bongiorno-Borbone, Lucilla; Melino, Gerry; Peschiaroli, Angelo.

In: Oncogenesis, Vol. 7, No. 8, 24.08.2018, p. 65.

Research output: Contribution to journalArticle

Gatti, V, Fierro, C, Compagnone, M, Giangrazi, F, Markert, EK, Bongiorno-Borbone, L, Melino, G & Peschiaroli, A 2018, 'ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells', Oncogenesis, vol. 7, no. 8, pp. 65. https://doi.org/10.1038/s41389-018-0073-3
Gatti V, Fierro C, Compagnone M, Giangrazi F, Markert EK, Bongiorno-Borbone L et al. ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells. Oncogenesis. 2018 Aug 24;7(8):65. https://doi.org/10.1038/s41389-018-0073-3
Gatti, Veronica ; Fierro, Claudia ; Compagnone, Mirco ; Giangrazi, Federica ; Markert, Elke Katrin ; Bongiorno-Borbone, Lucilla ; Melino, Gerry ; Peschiaroli, Angelo. / ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells. In: Oncogenesis. 2018 ; Vol. 7, No. 8. pp. 65.
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AB - Triple negative breast cancers (TNBC) represent the most aggressive and clinically relevant breast carcinomas. On the basis of specific molecular signature, the majority of TNBC can be classified as basal-like breast carcinoma. Here, we report data showing that in basal-like breast carcinoma cells ΔNp63 is capable of sustaining the production of the hyaluronic acid (HA), one of the major component of the extracellular matrix (ECM). At molecular level, we found that ΔNp63 regulates the expression of HA-related genes, such as the HA synthase HAS3, the hyaluronidase HYAL-1 and CD44, the major HA cell membrane receptor. By controlling this pathway, ∆Np63 contributes to maintain the self-renewal of breast cancer stem cells. Importantly, high HAS3 expression is a negative prognostic factor of TNBC patients. Our data suggest that in basal-type breast carcinoma ∆Np63 might favor a HA-rich microenviroment, which can sustain tumor proliferation and stemness.

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