μ3 Opiate receptor expression in lung and lung carcinoma: Ligand binding and coupling to nitric oxide release

C. Fimiani, E. Arcuri, A. Santoni, C. M. Rialas, T. V. Bilfinger, D. Peter, B. Salzet, G. B. Stefano

Research output: Contribution to journalArticle

Abstract

The μ3 opiate receptor subtype is expressed in human surgical specimens of both normal lung and non-small-cell lung carcinoma. Nitric oxide (NO) release is mediated through the μ3 receptor, and in lung carcinoma, morphine-stimulated NO release is significantly higher and prolonged than in normal lung. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis we show that specific μ opioid receptor transcripts are present in lung carcinoma and other cells with the μ3 profile. Our findings identify a unique role for the μ3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalCancer Letters
Volume146
Issue number1
DOIs
Publication statusPublished - Nov 1 1999

Fingerprint

Opioid Receptors
Nitric Oxide
Ligands
Carcinoma
Lung
Opiate Alkaloids
Opioid Peptides
Southern Blotting
Reverse Transcriptase Polymerase Chain Reaction
Non-Small Cell Lung Carcinoma
Morphine
Neoplasms

Keywords

  • μ
  • Alternative splicing
  • Cancer
  • Lung
  • Morphine
  • Neoplasia
  • Nitric oxide
  • Opioid receptor transcript

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Fimiani, C., Arcuri, E., Santoni, A., Rialas, C. M., Bilfinger, T. V., Peter, D., ... Stefano, G. B. (1999). μ3 Opiate receptor expression in lung and lung carcinoma: Ligand binding and coupling to nitric oxide release. Cancer Letters, 146(1), 45-51. https://doi.org/10.1016/S0304-3835(99)00227-X

μ3 Opiate receptor expression in lung and lung carcinoma : Ligand binding and coupling to nitric oxide release. / Fimiani, C.; Arcuri, E.; Santoni, A.; Rialas, C. M.; Bilfinger, T. V.; Peter, D.; Salzet, B.; Stefano, G. B.

In: Cancer Letters, Vol. 146, No. 1, 01.11.1999, p. 45-51.

Research output: Contribution to journalArticle

Fimiani, C, Arcuri, E, Santoni, A, Rialas, CM, Bilfinger, TV, Peter, D, Salzet, B & Stefano, GB 1999, 'μ3 Opiate receptor expression in lung and lung carcinoma: Ligand binding and coupling to nitric oxide release', Cancer Letters, vol. 146, no. 1, pp. 45-51. https://doi.org/10.1016/S0304-3835(99)00227-X
Fimiani, C. ; Arcuri, E. ; Santoni, A. ; Rialas, C. M. ; Bilfinger, T. V. ; Peter, D. ; Salzet, B. ; Stefano, G. B. / μ3 Opiate receptor expression in lung and lung carcinoma : Ligand binding and coupling to nitric oxide release. In: Cancer Letters. 1999 ; Vol. 146, No. 1. pp. 45-51.
@article{d1725226cb75450587821a80f94ab6e7,
title = "μ3 Opiate receptor expression in lung and lung carcinoma: Ligand binding and coupling to nitric oxide release",
abstract = "The μ3 opiate receptor subtype is expressed in human surgical specimens of both normal lung and non-small-cell lung carcinoma. Nitric oxide (NO) release is mediated through the μ3 receptor, and in lung carcinoma, morphine-stimulated NO release is significantly higher and prolonged than in normal lung. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis we show that specific μ opioid receptor transcripts are present in lung carcinoma and other cells with the μ3 profile. Our findings identify a unique role for the μ3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression. Copyright (C) 1999 Elsevier Science Ireland Ltd.",
keywords = "μ, Alternative splicing, Cancer, Lung, Morphine, Neoplasia, Nitric oxide, Opioid receptor transcript",
author = "C. Fimiani and E. Arcuri and A. Santoni and Rialas, {C. M.} and Bilfinger, {T. V.} and D. Peter and B. Salzet and Stefano, {G. B.}",
year = "1999",
month = "11",
day = "1",
doi = "10.1016/S0304-3835(99)00227-X",
language = "English",
volume = "146",
pages = "45--51",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - μ3 Opiate receptor expression in lung and lung carcinoma

T2 - Ligand binding and coupling to nitric oxide release

AU - Fimiani, C.

AU - Arcuri, E.

AU - Santoni, A.

AU - Rialas, C. M.

AU - Bilfinger, T. V.

AU - Peter, D.

AU - Salzet, B.

AU - Stefano, G. B.

PY - 1999/11/1

Y1 - 1999/11/1

N2 - The μ3 opiate receptor subtype is expressed in human surgical specimens of both normal lung and non-small-cell lung carcinoma. Nitric oxide (NO) release is mediated through the μ3 receptor, and in lung carcinoma, morphine-stimulated NO release is significantly higher and prolonged than in normal lung. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis we show that specific μ opioid receptor transcripts are present in lung carcinoma and other cells with the μ3 profile. Our findings identify a unique role for the μ3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - The μ3 opiate receptor subtype is expressed in human surgical specimens of both normal lung and non-small-cell lung carcinoma. Nitric oxide (NO) release is mediated through the μ3 receptor, and in lung carcinoma, morphine-stimulated NO release is significantly higher and prolonged than in normal lung. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis we show that specific μ opioid receptor transcripts are present in lung carcinoma and other cells with the μ3 profile. Our findings identify a unique role for the μ3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression. Copyright (C) 1999 Elsevier Science Ireland Ltd.

KW - μ

KW - Alternative splicing

KW - Cancer

KW - Lung

KW - Morphine

KW - Neoplasia

KW - Nitric oxide

KW - Opioid receptor transcript

UR - http://www.scopus.com/inward/record.url?scp=0032585763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032585763&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(99)00227-X

DO - 10.1016/S0304-3835(99)00227-X

M3 - Article

C2 - 10656608

AN - SCOPUS:0032585763

VL - 146

SP - 45

EP - 51

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -