1-(3-Trifluoromethylphenyl)piperazine (TFMPP) in the ventral tegmental area reduces the effect of desipramine in the forced swimming test in rats: possible role of serotonin receptors

Luigi Cervo, Giuliano Grignaschi, Elzbieta Nowakowska, Rosario Samanin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

1-(3-Trifluoromethylphenyl)piperazine (TFMPP), a serotonin1 (5-HT1) receptor agonist, injected i.p. in doses of 0.1 and 0.6 mg/kg, did not modify the immobility time of rats in the forced swimming test but significantly antagonized the effect of a 7 days treatment with 10 mg/kg per day desipramine (DMI). A similar effect was found on infusing 1 and 5 μg/μl TFMPP bilaterally into the ventral tegmental area (VTA). Infusion of 5 μg/μl TFMPP into the nucleus accumbens or into the globus pallidus did not modify the effect of DMI. The effect of 5 μg TFMPP infused into the VTA was prevented by the i.p. administration of 5 mg/kg metergoline, a non-selective serotonin receptor antagonist. Infusion of 5 μg/μl 8-hydroxy-2-(di-n-propylamino)tetralin, a specific 5-HT1A receptor agonist, into the VTA did not modify the effect of DMI. Besides acting as a 5-HT1B receptor agonist, TFMPP may also act on other 5-HT receptor types, but available evidence suggests that its former action is more important. It thus appears that 5-HT1 receptors in the VTA, presumably of the 5-HT1B type, act by preventing the anti-immobility effect of DMI. The role of VTA dopamine and non-dopamine cells in the effect of TFMPP is discussed.

Original languageEnglish
Pages (from-to)119-125
Number of pages7
JournalEuropean Journal of Pharmacology
Volume171
Issue number1
DOIs
Publication statusPublished - Nov 14 1989

Fingerprint

Ventral Tegmental Area
Desipramine
Serotonin Receptors
Serotonin 5-HT1 Receptor Agonists
Serotonin 5-HT1 Receptors
Metergoline
Receptor, Serotonin, 5-HT1B
8-Hydroxy-2-(di-n-propylamino)tetralin
Serotonin Antagonists
Receptor, Serotonin, 5-HT1A
Globus Pallidus
Nucleus Accumbens
1-(3-trifluoromethylphenyl)piperazine
Dopamine

Keywords

  • (Rat)
  • 5-HT receptor subtype
  • Desipramine
  • Forced swimming test
  • TFMPP (1-(3-trifluoromethylphenyl)piperazine)
  • Ventral tegmental area

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

1-(3-Trifluoromethylphenyl)piperazine (TFMPP) in the ventral tegmental area reduces the effect of desipramine in the forced swimming test in rats : possible role of serotonin receptors. / Cervo, Luigi; Grignaschi, Giuliano; Nowakowska, Elzbieta; Samanin, Rosario.

In: European Journal of Pharmacology, Vol. 171, No. 1, 14.11.1989, p. 119-125.

Research output: Contribution to journalArticle

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abstract = "1-(3-Trifluoromethylphenyl)piperazine (TFMPP), a serotonin1 (5-HT1) receptor agonist, injected i.p. in doses of 0.1 and 0.6 mg/kg, did not modify the immobility time of rats in the forced swimming test but significantly antagonized the effect of a 7 days treatment with 10 mg/kg per day desipramine (DMI). A similar effect was found on infusing 1 and 5 μg/μl TFMPP bilaterally into the ventral tegmental area (VTA). Infusion of 5 μg/μl TFMPP into the nucleus accumbens or into the globus pallidus did not modify the effect of DMI. The effect of 5 μg TFMPP infused into the VTA was prevented by the i.p. administration of 5 mg/kg metergoline, a non-selective serotonin receptor antagonist. Infusion of 5 μg/μl 8-hydroxy-2-(di-n-propylamino)tetralin, a specific 5-HT1A receptor agonist, into the VTA did not modify the effect of DMI. Besides acting as a 5-HT1B receptor agonist, TFMPP may also act on other 5-HT receptor types, but available evidence suggests that its former action is more important. It thus appears that 5-HT1 receptors in the VTA, presumably of the 5-HT1B type, act by preventing the anti-immobility effect of DMI. The role of VTA dopamine and non-dopamine cells in the effect of TFMPP is discussed.",
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