1-Hour plasma glucose in obese youth

M. Manco, E. Miraglia Del Giudice, M. R. Spreghini, M. Cappa, L. Perrone, C. Brufani, C. Rustico, G. Morino, S. Caprio

Research output: Contribution to journalArticle

Abstract

Adults with normal glucose tolerance (NGT) but exaggerated plasma glucose excursion at 1 h (1HPG) following the oral glucose tolerance test (OGTT) have significantly higher risk of developing impaired glucose tolerance (IGT) or diabetes. Aim of the study will be to characterize the metabolic phenotype of NGT obese youth according to values of 1HPG. To accomplish this aim, obese patients (N = 1,454; 761 men; 79 IGT; BMI z-score 2.56 ± 0.16 SDS; age 11 ± 0.7 years) from two data sets were analyzed. In all patients, empirical parameters of insulin metabolism were calculated in fasting condition and following an OGTT (1.75 mg of glucose per kilogram/ body weight). Receiver-operating characteristic (ROC) analysis was performed in the first group (training set, N = 920) to establish the cutoff value of 1HPG best identifying IGT. The second set (validation set, N = 534) served to verify the goodness of the model and the identified cutoff values. 1HPG ≥ 132.5 mg/dl identified IGT with 80.8% sensitivity and 74.3% specificity in the training set (AUC 0.855, 95% CI 0.808-0.902, P

Original languageEnglish
Pages (from-to)435-443
Number of pages9
JournalActa Diabetologica
Volume49
Issue number6
DOIs
Publication statusPublished - 2012

Keywords

  • Impaired glucose tolerance
  • Insulin resistance
  • Insulin secretion
  • Metabolic syndrome
  • Obese children
  • Oral glucose tolerance test

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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