1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease: The PLATFORM Study

Pamela S. Douglas, Bernard De Bruyne, Gianluca Pontone, Manesh R. Patel, Bjarne L. Norgaard, Robert A. Byrne, Nick Curzen, Ian Purcell, Matthias Gutberlet, Gilles Rioufol, Ulrich Hink, Herwig Walter Schuchlenz, Gudrun Feuchtner, Martine Gilard, Daniele Andreini, Jesper M. Jensen, Martin Hadamitzky, Karen Chiswell, Derek Cyr, Alan WilkFurong Wang, Campbell Rogers, Mark A. Hlatky

Research output: Contribution to journalArticle

Abstract

Background Coronary computed tomographic angiography (CTA) plus estimation of fractional flow reserve using CTA (FFRCT) safely and effectively guides initial care over 90 days in patients with stable chest pain. Longer-term outcomes are unknown. Objectives The study sought to determine the 1-year clinical, economic, and quality-of-life (QOL) outcomes of using FFRCT instead of usual care. Methods Consecutive patients with stable, new onset chest pain were managed by either usual testing (n = 287) or CTA (n = 297) with selective FFRCT (submitted in 201, analyzed in 177); 581 of 584 (99.5%) completed 1-year follow-up. Endpoints were adjudicated major adverse cardiac events (MACE) (death, myocardial infarction, unplanned revascularization), total medical costs, and QOL. Results Patients averaged 61 years of age with a mean 49% pre-test probability of coronary artery disease. At 1 year, MACE events were infrequent, with 2 in each arm of the planned invasive group and 1 in the planned noninvasive cohort (usual care strategy). In the planned invasive stratum, mean costs were 33% lower with CTA and selective FFRCT ($8,127 vs. $12,145 usual care; p < 0.0001); in the planned noninvasive stratum, mean costs did not differ when using an FFRCT cost weight of zero ($3,049 FFRCT vs. $2,579; p = 0.82), but were higher when using an FFRCT cost weight equal to CTA. QOL scores improved overall at 1 year (p < 0.001), with similar improvements in both groups, apart from the 5-item EuroQOL scale scores in the noninvasive stratum (mean change of 0.12 for FFRCT vs. 0.07 for usual care; p = 0.02). Conclusions In patients with stable chest pain and planned invasive coronary angiography, care guided by CTA and selective FFRCT was associated with equivalent clinical outcomes and QOL, and lower costs, compared with usual care over 1-year follow-up. (The PLATFORM Study: Prospective LongitudinAl Trial of FFRct: Outcome and Resource IMpacts [PLATFORM]; NCT01943903)

Original languageEnglish
Pages (from-to)435-445
Number of pages11
JournalJournal of the American College of Cardiology
Volume68
Issue number5
DOIs
Publication statusPublished - Aug 2 2016

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Coronary Disease
Patient Care
Angiography
Costs and Cost Analysis
Chest Pain
Quality of Life
Weights and Measures
Coronary Angiography
Longitudinal Studies
Coronary Artery Disease
Myocardial Infarction
Economics
Prospective Studies

Keywords

  • economic outcomes
  • fractional flow reserve using computed tomography
  • major adverse cardiac events
  • quality of life

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease : The PLATFORM Study. / Douglas, Pamela S.; De Bruyne, Bernard; Pontone, Gianluca; Patel, Manesh R.; Norgaard, Bjarne L.; Byrne, Robert A.; Curzen, Nick; Purcell, Ian; Gutberlet, Matthias; Rioufol, Gilles; Hink, Ulrich; Schuchlenz, Herwig Walter; Feuchtner, Gudrun; Gilard, Martine; Andreini, Daniele; Jensen, Jesper M.; Hadamitzky, Martin; Chiswell, Karen; Cyr, Derek; Wilk, Alan; Wang, Furong; Rogers, Campbell; Hlatky, Mark A.

In: Journal of the American College of Cardiology, Vol. 68, No. 5, 02.08.2016, p. 435-445.

Research output: Contribution to journalArticle

Douglas, PS, De Bruyne, B, Pontone, G, Patel, MR, Norgaard, BL, Byrne, RA, Curzen, N, Purcell, I, Gutberlet, M, Rioufol, G, Hink, U, Schuchlenz, HW, Feuchtner, G, Gilard, M, Andreini, D, Jensen, JM, Hadamitzky, M, Chiswell, K, Cyr, D, Wilk, A, Wang, F, Rogers, C & Hlatky, MA 2016, '1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease: The PLATFORM Study', Journal of the American College of Cardiology, vol. 68, no. 5, pp. 435-445. https://doi.org/10.1016/j.jacc.2016.05.057
Douglas, Pamela S. ; De Bruyne, Bernard ; Pontone, Gianluca ; Patel, Manesh R. ; Norgaard, Bjarne L. ; Byrne, Robert A. ; Curzen, Nick ; Purcell, Ian ; Gutberlet, Matthias ; Rioufol, Gilles ; Hink, Ulrich ; Schuchlenz, Herwig Walter ; Feuchtner, Gudrun ; Gilard, Martine ; Andreini, Daniele ; Jensen, Jesper M. ; Hadamitzky, Martin ; Chiswell, Karen ; Cyr, Derek ; Wilk, Alan ; Wang, Furong ; Rogers, Campbell ; Hlatky, Mark A. / 1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease : The PLATFORM Study. In: Journal of the American College of Cardiology. 2016 ; Vol. 68, No. 5. pp. 435-445.
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TY - JOUR

T1 - 1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease

T2 - The PLATFORM Study

AU - Douglas, Pamela S.

AU - De Bruyne, Bernard

AU - Pontone, Gianluca

AU - Patel, Manesh R.

AU - Norgaard, Bjarne L.

AU - Byrne, Robert A.

AU - Curzen, Nick

AU - Purcell, Ian

AU - Gutberlet, Matthias

AU - Rioufol, Gilles

AU - Hink, Ulrich

AU - Schuchlenz, Herwig Walter

AU - Feuchtner, Gudrun

AU - Gilard, Martine

AU - Andreini, Daniele

AU - Jensen, Jesper M.

AU - Hadamitzky, Martin

AU - Chiswell, Karen

AU - Cyr, Derek

AU - Wilk, Alan

AU - Wang, Furong

AU - Rogers, Campbell

AU - Hlatky, Mark A.

PY - 2016/8/2

Y1 - 2016/8/2

N2 - Background Coronary computed tomographic angiography (CTA) plus estimation of fractional flow reserve using CTA (FFRCT) safely and effectively guides initial care over 90 days in patients with stable chest pain. Longer-term outcomes are unknown. Objectives The study sought to determine the 1-year clinical, economic, and quality-of-life (QOL) outcomes of using FFRCT instead of usual care. Methods Consecutive patients with stable, new onset chest pain were managed by either usual testing (n = 287) or CTA (n = 297) with selective FFRCT (submitted in 201, analyzed in 177); 581 of 584 (99.5%) completed 1-year follow-up. Endpoints were adjudicated major adverse cardiac events (MACE) (death, myocardial infarction, unplanned revascularization), total medical costs, and QOL. Results Patients averaged 61 years of age with a mean 49% pre-test probability of coronary artery disease. At 1 year, MACE events were infrequent, with 2 in each arm of the planned invasive group and 1 in the planned noninvasive cohort (usual care strategy). In the planned invasive stratum, mean costs were 33% lower with CTA and selective FFRCT ($8,127 vs. $12,145 usual care; p < 0.0001); in the planned noninvasive stratum, mean costs did not differ when using an FFRCT cost weight of zero ($3,049 FFRCT vs. $2,579; p = 0.82), but were higher when using an FFRCT cost weight equal to CTA. QOL scores improved overall at 1 year (p < 0.001), with similar improvements in both groups, apart from the 5-item EuroQOL scale scores in the noninvasive stratum (mean change of 0.12 for FFRCT vs. 0.07 for usual care; p = 0.02). Conclusions In patients with stable chest pain and planned invasive coronary angiography, care guided by CTA and selective FFRCT was associated with equivalent clinical outcomes and QOL, and lower costs, compared with usual care over 1-year follow-up. (The PLATFORM Study: Prospective LongitudinAl Trial of FFRct: Outcome and Resource IMpacts [PLATFORM]; NCT01943903)

AB - Background Coronary computed tomographic angiography (CTA) plus estimation of fractional flow reserve using CTA (FFRCT) safely and effectively guides initial care over 90 days in patients with stable chest pain. Longer-term outcomes are unknown. Objectives The study sought to determine the 1-year clinical, economic, and quality-of-life (QOL) outcomes of using FFRCT instead of usual care. Methods Consecutive patients with stable, new onset chest pain were managed by either usual testing (n = 287) or CTA (n = 297) with selective FFRCT (submitted in 201, analyzed in 177); 581 of 584 (99.5%) completed 1-year follow-up. Endpoints were adjudicated major adverse cardiac events (MACE) (death, myocardial infarction, unplanned revascularization), total medical costs, and QOL. Results Patients averaged 61 years of age with a mean 49% pre-test probability of coronary artery disease. At 1 year, MACE events were infrequent, with 2 in each arm of the planned invasive group and 1 in the planned noninvasive cohort (usual care strategy). In the planned invasive stratum, mean costs were 33% lower with CTA and selective FFRCT ($8,127 vs. $12,145 usual care; p < 0.0001); in the planned noninvasive stratum, mean costs did not differ when using an FFRCT cost weight of zero ($3,049 FFRCT vs. $2,579; p = 0.82), but were higher when using an FFRCT cost weight equal to CTA. QOL scores improved overall at 1 year (p < 0.001), with similar improvements in both groups, apart from the 5-item EuroQOL scale scores in the noninvasive stratum (mean change of 0.12 for FFRCT vs. 0.07 for usual care; p = 0.02). Conclusions In patients with stable chest pain and planned invasive coronary angiography, care guided by CTA and selective FFRCT was associated with equivalent clinical outcomes and QOL, and lower costs, compared with usual care over 1-year follow-up. (The PLATFORM Study: Prospective LongitudinAl Trial of FFRct: Outcome and Resource IMpacts [PLATFORM]; NCT01943903)

KW - economic outcomes

KW - fractional flow reserve using computed tomography

KW - major adverse cardiac events

KW - quality of life

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