+10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution

Beatrice Arosio; Luigi Bergamaschini; Lorenza Galimberti; Caterina La Porta; Mariella Zanetti; Carmen Calabresi; E. Scarpini; Giorgio Annoni; Carlo Vergani

doi:10.1016/j.mad.2007.07.006

+10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution

Beatrice Arosio, Luigi Bergamaschini, Lorenza Galimberti, Caterina La Porta, Mariella Zanetti, Carmen Calabresi, E. Scarpini, Giorgio Annoni, Carlo Vergani

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article

Abstract

Transforming growth factor-β1 (TGF-β1) acts as an immunosuppressant by inhibiting the expression of several pro-inflammatory cytokines. Its gene contains single nucleotide polymorphisms (SNPs) at codon +10 (T → C) and +25 (G → C) that appear to influence the level of expression of TGF-β1. We investigated these SNPs in 198 healthy controls (HC), 193 patients with Alzheimer's disease (AD) and 48 patients with mild cognitive impairment (MCI). Among the latter, after a 4-year follow-up, 21 were diagnosed as AD (MCI → AD) while 18 did not progress (stable MCI). We observed that both the +10 C allele and the CC genotype were over-represented in AD when compared to HC. These variants significantly raised the risk of disease independently of the status of apolipoprotein E4. The CC genotype was also over-expressed in MCI, especially in MCI → AD. These results suggest that TGF-β1 may be one of the early markers involved in the inflammatory mechanisms underlying the pathogenesis of AD.

Original language	English
Pages (from-to)	553-557
Number of pages	5
Journal	Mechanisms of Ageing and Development
Volume	128
Issue number	10
DOIs	https://doi.org/10.1016/j.mad.2007.07.006
Publication status	Published - Oct 2007

Keywords

Alzheimer's disease
Cytokines
Gene polymorphisms
Inflammation
TGF-β1

ASJC Scopus subject areas

Ageing
Biochemistry
Developmental Biology
Developmental Neuroscience

Access to Document

10.1016/j.mad.2007.07.006

Fingerprint Dive into the research topics of '+10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution'. Together they form a unique fingerprint.

Cite this

Arosio, B., Bergamaschini, L., Galimberti, L., La Porta, C., Zanetti, M., Calabresi, C., Scarpini, E., Annoni, G., & Vergani, C. (2007). +10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution. Mechanisms of Ageing and Development, 128(10), 553-557. https://doi.org/10.1016/j.mad.2007.07.006

+10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution. / Arosio, Beatrice; Bergamaschini, Luigi; Galimberti, Lorenza; La Porta, Caterina; Zanetti, Mariella; Calabresi, Carmen; Scarpini, E.; Annoni, Giorgio; Vergani, Carlo.

In: Mechanisms of Ageing and Development, Vol. 128, No. 10, 10.2007, p. 553-557.

Research output: Contribution to journal › Article

Arosio, B, Bergamaschini, L, Galimberti, L, La Porta, C, Zanetti, M, Calabresi, C, Scarpini, E, Annoni, G & Vergani, C 2007, '+10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution', Mechanisms of Ageing and Development, vol. 128, no. 10, pp. 553-557. https://doi.org/10.1016/j.mad.2007.07.006

Arosio, Beatrice ; Bergamaschini, Luigi ; Galimberti, Lorenza ; La Porta, Caterina ; Zanetti, Mariella ; Calabresi, Carmen ; Scarpini, E. ; Annoni, Giorgio ; Vergani, Carlo. / +10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution. In: Mechanisms of Ageing and Development. 2007 ; Vol. 128, No. 10. pp. 553-557.

@article{212230da3acc4e398731da186a926b40,

title = "+10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution",

abstract = "Transforming growth factor-β1 (TGF-β1) acts as an immunosuppressant by inhibiting the expression of several pro-inflammatory cytokines. Its gene contains single nucleotide polymorphisms (SNPs) at codon +10 (T → C) and +25 (G → C) that appear to influence the level of expression of TGF-β1. We investigated these SNPs in 198 healthy controls (HC), 193 patients with Alzheimer's disease (AD) and 48 patients with mild cognitive impairment (MCI). Among the latter, after a 4-year follow-up, 21 were diagnosed as AD (MCI → AD) while 18 did not progress (stable MCI). We observed that both the +10 C allele and the CC genotype were over-represented in AD when compared to HC. These variants significantly raised the risk of disease independently of the status of apolipoprotein E4. The CC genotype was also over-expressed in MCI, especially in MCI → AD. These results suggest that TGF-β1 may be one of the early markers involved in the inflammatory mechanisms underlying the pathogenesis of AD.",

keywords = "Alzheimer's disease, Cytokines, Gene polymorphisms, Inflammation, TGF-β1",

author = "Beatrice Arosio and Luigi Bergamaschini and Lorenza Galimberti and {La Porta}, Caterina and Mariella Zanetti and Carmen Calabresi and E. Scarpini and Giorgio Annoni and Carlo Vergani",

year = "2007",

month = oct,

doi = "10.1016/j.mad.2007.07.006",

language = "English",

volume = "128",

pages = "553--557",

journal = "Mechanisms of Ageing and Development",

issn = "0047-6374",

publisher = "Elsevier Ireland Ltd",

number = "10",

}

TY - JOUR

T1 - +10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution

AU - Arosio, Beatrice

AU - Bergamaschini, Luigi

AU - Galimberti, Lorenza

AU - La Porta, Caterina

AU - Zanetti, Mariella

AU - Calabresi, Carmen

AU - Scarpini, E.

AU - Annoni, Giorgio

AU - Vergani, Carlo

PY - 2007/10

Y1 - 2007/10

N2 - Transforming growth factor-β1 (TGF-β1) acts as an immunosuppressant by inhibiting the expression of several pro-inflammatory cytokines. Its gene contains single nucleotide polymorphisms (SNPs) at codon +10 (T → C) and +25 (G → C) that appear to influence the level of expression of TGF-β1. We investigated these SNPs in 198 healthy controls (HC), 193 patients with Alzheimer's disease (AD) and 48 patients with mild cognitive impairment (MCI). Among the latter, after a 4-year follow-up, 21 were diagnosed as AD (MCI → AD) while 18 did not progress (stable MCI). We observed that both the +10 C allele and the CC genotype were over-represented in AD when compared to HC. These variants significantly raised the risk of disease independently of the status of apolipoprotein E4. The CC genotype was also over-expressed in MCI, especially in MCI → AD. These results suggest that TGF-β1 may be one of the early markers involved in the inflammatory mechanisms underlying the pathogenesis of AD.

AB - Transforming growth factor-β1 (TGF-β1) acts as an immunosuppressant by inhibiting the expression of several pro-inflammatory cytokines. Its gene contains single nucleotide polymorphisms (SNPs) at codon +10 (T → C) and +25 (G → C) that appear to influence the level of expression of TGF-β1. We investigated these SNPs in 198 healthy controls (HC), 193 patients with Alzheimer's disease (AD) and 48 patients with mild cognitive impairment (MCI). Among the latter, after a 4-year follow-up, 21 were diagnosed as AD (MCI → AD) while 18 did not progress (stable MCI). We observed that both the +10 C allele and the CC genotype were over-represented in AD when compared to HC. These variants significantly raised the risk of disease independently of the status of apolipoprotein E4. The CC genotype was also over-expressed in MCI, especially in MCI → AD. These results suggest that TGF-β1 may be one of the early markers involved in the inflammatory mechanisms underlying the pathogenesis of AD.

KW - Alzheimer's disease

KW - Cytokines

KW - Gene polymorphisms

KW - Inflammation

KW - TGF-β1

UR - http://www.scopus.com/inward/record.url?scp=34848849014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34848849014&partnerID=8YFLogxK

U2 - 10.1016/j.mad.2007.07.006

DO - 10.1016/j.mad.2007.07.006

M3 - Article

C2 - 17889927

AN - SCOPUS:34848849014

VL - 128

SP - 553

EP - 557

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - 10

ER -