Abstract
INTRODUCTION: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.
MATERIALS AND METHODS: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.
RESULTS: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).
CONCLUSION: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.
Original language | English |
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Pages (from-to) | 586-593 |
Number of pages | 8 |
Journal | Cancer Investigation |
Volume | 35 |
Issue number | 9 |
DOIs | |
Publication status | Published - Oct 21 2017 |
Keywords
- Aged
- Carbon Radioisotopes
- Choline
- Disease-Free Survival
- Humans
- Kallikreins
- Kaplan-Meier Estimate
- Lymph Nodes
- Lymphatic Metastasis
- Male
- Positron Emission Tomography Computed Tomography
- Predictive Value of Tests
- Prostate-Specific Antigen
- Prostatic Neoplasms
- Radiopharmaceuticals
- Radiosurgery
- Retrospective Studies
- Time Factors
- Treatment Outcome
- Journal Article