11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

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Abstract

INTRODUCTION: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.

MATERIALS AND METHODS: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.

RESULTS: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).

CONCLUSION: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

Original languageEnglish
Pages (from-to)586-593
Number of pages8
JournalCancer Investigation
Volume35
Issue number9
DOIs
Publication statusPublished - Oct 21 2017

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Choline
Prostatic Neoplasms
Radiotherapy
Lymph Nodes
Neoplasm Metastasis
Disease-Free Survival
Neoplasms

Keywords

  • Aged
  • Carbon Radioisotopes
  • Choline
  • Disease-Free Survival
  • Humans
  • Kallikreins
  • Kaplan-Meier Estimate
  • Lymph Nodes
  • Lymphatic Metastasis
  • Male
  • Positron Emission Tomography Computed Tomography
  • Predictive Value of Tests
  • Prostate-Specific Antigen
  • Prostatic Neoplasms
  • Radiopharmaceuticals
  • Radiosurgery
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Journal Article

Cite this

@article{72a5d9b133614c0abcc015ce93758f67,
title = "11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer",
abstract = "INTRODUCTION: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.MATERIALS AND METHODS: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.RESULTS: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7{\%}), partial response in 9 metastases (38{\%}).CONCLUSION: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.",
keywords = "Aged, Carbon Radioisotopes, Choline, Disease-Free Survival, Humans, Kallikreins, Kaplan-Meier Estimate, Lymph Nodes, Lymphatic Metastasis, Male, Positron Emission Tomography Computed Tomography, Predictive Value of Tests, Prostate-Specific Antigen, Prostatic Neoplasms, Radiopharmaceuticals, Radiosurgery, Retrospective Studies, Time Factors, Treatment Outcome, Journal Article",
author = "Ciro Franzese and Egesta Lopci and {Di Brina}, Lucia and D'Agostino, {Giuseppe Roberto} and Pierina Navarria and Pietro Mancosu and Stefano Tomatis and Arturo Chiti and Marta Scorsetti",
year = "2017",
month = "10",
day = "21",
doi = "10.1080/07357907.2017.1375116",
language = "English",
volume = "35",
pages = "586--593",
journal = "Cancer Investigation",
issn = "0735-7907",
publisher = "Informa Healthcare",
number = "9",

}

TY - JOUR

T1 - 11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

AU - Franzese, Ciro

AU - Lopci, Egesta

AU - Di Brina, Lucia

AU - D'Agostino, Giuseppe Roberto

AU - Navarria, Pierina

AU - Mancosu, Pietro

AU - Tomatis, Stefano

AU - Chiti, Arturo

AU - Scorsetti, Marta

PY - 2017/10/21

Y1 - 2017/10/21

N2 - INTRODUCTION: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.MATERIALS AND METHODS: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.RESULTS: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).CONCLUSION: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

AB - INTRODUCTION: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.MATERIALS AND METHODS: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.RESULTS: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).CONCLUSION: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

KW - Aged

KW - Carbon Radioisotopes

KW - Choline

KW - Disease-Free Survival

KW - Humans

KW - Kallikreins

KW - Kaplan-Meier Estimate

KW - Lymph Nodes

KW - Lymphatic Metastasis

KW - Male

KW - Positron Emission Tomography Computed Tomography

KW - Predictive Value of Tests

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms

KW - Radiopharmaceuticals

KW - Radiosurgery

KW - Retrospective Studies

KW - Time Factors

KW - Treatment Outcome

KW - Journal Article

U2 - 10.1080/07357907.2017.1375116

DO - 10.1080/07357907.2017.1375116

M3 - Article

C2 - 28980836

VL - 35

SP - 586

EP - 593

JO - Cancer Investigation

JF - Cancer Investigation

SN - 0735-7907

IS - 9

ER -