11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.

MATERIALS AND METHODS: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.

RESULTS: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).

CONCLUSION: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

Original languageEnglish
Pages (from-to)586-593
Number of pages8
JournalCancer Investigation
Volume35
Issue number9
DOIs
Publication statusPublished - Oct 21 2017

Keywords

  • Aged
  • Carbon Radioisotopes
  • Choline
  • Disease-Free Survival
  • Humans
  • Kallikreins
  • Kaplan-Meier Estimate
  • Lymph Nodes
  • Lymphatic Metastasis
  • Male
  • Positron Emission Tomography Computed Tomography
  • Predictive Value of Tests
  • Prostate-Specific Antigen
  • Prostatic Neoplasms
  • Radiopharmaceuticals
  • Radiosurgery
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Journal Article

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