11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

Ciro Franzese; Egesta Lopci; Lucia Di Brina; Giuseppe Roberto D'Agostino; Pierina Navarria; Pietro Mancosu; Stefano Tomatis; Arturo Chiti; Marta Scorsetti

doi:10.1080/07357907.2017.1375116

11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

Ciro Franzese, Egesta Lopci, Lucia Di Brina, Giuseppe Roberto D'Agostino, Pierina Navarria, Pietro Mancosu, Stefano Tomatis, Arturo Chiti, Marta Scorsetti

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.

MATERIALS AND METHODS: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.

RESULTS: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).

CONCLUSION: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

Original language	English
Pages (from-to)	586-593
Number of pages	8
Journal	Cancer Investigation
Volume	35
Issue number	9
DOIs	https://doi.org/10.1080/07357907.2017.1375116
Publication status	Published - Oct 21 2017

Keywords

Aged
Carbon Radioisotopes
Choline
Disease-Free Survival
Humans
Kallikreins
Kaplan-Meier Estimate
Lymph Nodes
Lymphatic Metastasis
Male
Positron Emission Tomography Computed Tomography
Predictive Value of Tests
Prostate-Specific Antigen
Prostatic Neoplasms
Radiopharmaceuticals
Radiosurgery
Retrospective Studies
Time Factors
Treatment Outcome
Journal Article

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10.1080/07357907.2017.1375116

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title = "11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer",

abstract = "INTRODUCTION: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.MATERIALS AND METHODS: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.RESULTS: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).CONCLUSION: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.",

keywords = "Aged, Carbon Radioisotopes, Choline, Disease-Free Survival, Humans, Kallikreins, Kaplan-Meier Estimate, Lymph Nodes, Lymphatic Metastasis, Male, Positron Emission Tomography Computed Tomography, Predictive Value of Tests, Prostate-Specific Antigen, Prostatic Neoplasms, Radiopharmaceuticals, Radiosurgery, Retrospective Studies, Time Factors, Treatment Outcome, Journal Article",

author = "Ciro Franzese and Egesta Lopci and {Di Brina}, Lucia and D'Agostino, {Giuseppe Roberto} and Pierina Navarria and Pietro Mancosu and Stefano Tomatis and Arturo Chiti and Marta Scorsetti",

year = "2017",

month = oct,

day = "21",

doi = "10.1080/07357907.2017.1375116",

language = "English",

volume = "35",

pages = "586--593",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Informa Healthcare",

number = "9",

}

TY - JOUR

T1 - 11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

AU - Franzese, Ciro

AU - Lopci, Egesta

AU - Di Brina, Lucia

AU - D'Agostino, Giuseppe Roberto

AU - Navarria, Pierina

AU - Mancosu, Pietro

AU - Tomatis, Stefano

AU - Chiti, Arturo

AU - Scorsetti, Marta

PY - 2017/10/21

Y1 - 2017/10/21

N2 - INTRODUCTION: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.MATERIALS AND METHODS: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.RESULTS: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).CONCLUSION: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

AB - INTRODUCTION: aim is outcome of 11C-Choline-PET guided SBRT on lymph node metastases.MATERIALS AND METHODS: patients with 1 - 4 lymph node metastases detected by 11C-choline-PET were treated with SBRT. Toxicity, treated metastases control and Progression Free Survival were computed.RESULTS: twenty-six patients, 38 lymph node metastases were irradiated. No grade ≥ 2 toxicity. Median PSA-nadir after RT was 1.02 ng/mL. Post-treatment 11C-Choline-PET showed metabolic complete response in 17 metastases (44,7%), partial response in 9 metastases (38%).CONCLUSION: SBRT is effective and safe for lymph node metastases. PET is important in identification of gross tumor and evaluation of the response.

KW - Aged

KW - Carbon Radioisotopes

KW - Choline

KW - Disease-Free Survival

KW - Humans

KW - Kallikreins

KW - Kaplan-Meier Estimate

KW - Lymph Nodes

KW - Lymphatic Metastasis

KW - Male

KW - Positron Emission Tomography Computed Tomography

KW - Predictive Value of Tests

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms

KW - Radiopharmaceuticals

KW - Radiosurgery

KW - Retrospective Studies

KW - Time Factors

KW - Treatment Outcome

KW - Journal Article

U2 - 10.1080/07357907.2017.1375116

DO - 10.1080/07357907.2017.1375116

M3 - Article

C2 - 28980836

VL - 35

SP - 586

EP - 593

JO - Cancer Investigation

JF - Cancer Investigation

SN - 0735-7907

IS - 9

ER -

11C-Choline-Pet Guided Stereotactic Body Radiation Therapy for Lymph Node Metastases in Oligometastatic Prostate Cancer

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Keywords

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