11C-Choline Positron Emission Tomography/Computerized Tomography for Preoperative Lymph-Node Staging in Intermediate-Risk and High-Risk Prostate Cancer: Comparison with Clinical Staging Nomograms

Riccardo Schiavina, Vincenzo Scattoni, Paolo Castellucci, Maria Picchio, Barbara Corti, Alberto Briganti, Alessandro Franceschelli, Francesco Sanguedolce, Alessandro Bertaccini, Moshen Farsad, Giampiero Giovacchini, Stefano Fanti, Walter Franco Grigioni, Ferruccio Fazio, Francesco Montorsi, Patrizio Rigatti, Giuseppe Martorana

Research output: Contribution to journalArticle

Abstract

Background: Conventional imaging (CI) techniques are inadequate for lymph node (LN) staging in prostate cancer (PCa). Objectives: To assess the accuracy of 11C-Choline positron emission tomography/computerized tomography (PET/CT) for LN staging in intermediate-risk and high-risk PCa and to compare it with two currently used nomograms. Design, Setting, and Participants: From January 2007 to September 2007, 57 PCa patients at intermediate risk (n = 27) or high risk (n = 30) were enrolled at two academic centres. All patients underwent preoperative PET/CT and radical prostatectomy with extended pelvic LN dissection (PLND). Risk of LN metastasis (LNM) was assessed using available nomograms. Measurements: Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and number of correctly recognized cases for LNM detection at PET/CT were assessed. The accuracy of PET/CT for LNM detection was compared with the accuracy of nomograms for LNM prediction by using receiver operating characteristic (ROC) analysis. Results and Limitations: Fifteen patients (26%) had LNMs, and a total of 41 LNMs were identified. On a patient analysis, sensitivity, specificity, PPV, NPV, and number of correctly recognized cases at PET/CT were 60.0%, 97.6%, 90.0%, 87.2%, and 87.7% while, on node analysis, these numbers were 41.4%, 99.8%, 94.4%, 97.2%, and 97.1%. The mean diameter (in mm) of the metastatic deposit of true-positive LNs was significantly higher than that of false-negative LNs (9.2 vs 4.2; p = 0.001). PET/CT showed higher specificity and accuracy than the nomograms; however, in pairwise comparison, the areas under the curve (AUCs) were not statistically different (all p values >0.05). Conclusions: In patients with intermediate-risk and high-risk PCa, 11C-Choline PET/CT has quite a low sensitivity for LNM detection but performed better than clinical nomograms, with equal sensitivity and better specificity.

Original languageEnglish
Pages (from-to)392-401
Number of pages10
JournalEuropean Urology
Volume54
Issue number2
DOIs
Publication statusPublished - Aug 2008

Keywords

  • C-Choline-PET/TC
  • Imaging
  • Lymph node metastasis
  • Nomogram
  • Pelvic lymph node dissection
  • Prostate cancer
  • Radical prostatectomy
  • Staging

ASJC Scopus subject areas

  • Urology

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    Schiavina, R., Scattoni, V., Castellucci, P., Picchio, M., Corti, B., Briganti, A., Franceschelli, A., Sanguedolce, F., Bertaccini, A., Farsad, M., Giovacchini, G., Fanti, S., Grigioni, W. F., Fazio, F., Montorsi, F., Rigatti, P., & Martorana, G. (2008). 11C-Choline Positron Emission Tomography/Computerized Tomography for Preoperative Lymph-Node Staging in Intermediate-Risk and High-Risk Prostate Cancer: Comparison with Clinical Staging Nomograms. European Urology, 54(2), 392-401. https://doi.org/10.1016/j.eururo.2008.04.030