[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy

A. Gerhard, R. B. Banati, G. B. Goerres, A. Cagnin, R. Myers, R. N. Gunn, F. Turkheimer, C. D. Good, C. J. Mathias, N. Quinn, J. Schwarz, D. J. Brooks

Research output: Contribution to journalArticlepeer-review

Abstract

Microglia, the brain's intrinsic macrophages, bind (R)-PK11195 when activated by neuronal injury. The authors used [11C](R)-PK11195 PET to localize in vivo microglial activation in patients with multiple system atrophy (MSA). Increased [11C](R)-PK11195 binding was primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an indicator of disease activity, [11C](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA.

Original languageEnglish
Pages (from-to)686-689
Number of pages4
JournalNeurology
Volume61
Issue number5
Publication statusPublished - Sep 9 2003

ASJC Scopus subject areas

  • Neuroscience(all)

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