12-year-old boy with multiple brain masses

Case of month january 2010

Luca Massimi, Massimo Caldarelli, Quintino Giorgio D'Alessandris, Massimo Rollo, Libero Lauriola, Felice Giangaspero, Concezio Di Rocco

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The occurrence of more than one brain tumor in a single patient is not new, resulting from RT- or CT-induced neoplasms, syndromes or casual association. We report on the exceptional case of a 12-year-old boy harboring three different brain tumors with no definite correlation. The first MRI showed a medulloblastoma with signs of infratentorial and supratentorial tumor spreading, including a small frontal mass. Despite the good response to surgical and adjuvant treatment, the frontal mass remained unchanged and was excised, revealing a lipoastrocytoma. Finally, the possible local recurrence of the original medulloblastoma was a pilocytic astrocytoma with post-radiation alterations. Explanations of this very unusual association include radio-induced tumors, second tumors developing from remnants of medulloblastoma cancer stem cells, or the changing histology after adjuvant therapy.

Original languageEnglish
Pages (from-to)679-682
Number of pages4
JournalBrain Pathology
Volume20
Issue number3
DOIs
Publication statusPublished - May 2010

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Medulloblastoma
Brain Neoplasms
Brain
Supratentorial Neoplasms
Infratentorial Neoplasms
Neoplasms
Neoplastic Stem Cells
Astrocytoma
Radio
Histology
Radiation
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Massimi, L., Caldarelli, M., D'Alessandris, Q. G., Rollo, M., Lauriola, L., Giangaspero, F., & Rocco, C. D. (2010). 12-year-old boy with multiple brain masses: Case of month january 2010. Brain Pathology, 20(3), 679-682. https://doi.org/10.1111/j.1750-3639.2010.00381.x

12-year-old boy with multiple brain masses : Case of month january 2010. / Massimi, Luca; Caldarelli, Massimo; D'Alessandris, Quintino Giorgio; Rollo, Massimo; Lauriola, Libero; Giangaspero, Felice; Rocco, Concezio Di.

In: Brain Pathology, Vol. 20, No. 3, 05.2010, p. 679-682.

Research output: Contribution to journalArticle

Massimi, L, Caldarelli, M, D'Alessandris, QG, Rollo, M, Lauriola, L, Giangaspero, F & Rocco, CD 2010, '12-year-old boy with multiple brain masses: Case of month january 2010', Brain Pathology, vol. 20, no. 3, pp. 679-682. https://doi.org/10.1111/j.1750-3639.2010.00381.x
Massimi, Luca ; Caldarelli, Massimo ; D'Alessandris, Quintino Giorgio ; Rollo, Massimo ; Lauriola, Libero ; Giangaspero, Felice ; Rocco, Concezio Di. / 12-year-old boy with multiple brain masses : Case of month january 2010. In: Brain Pathology. 2010 ; Vol. 20, No. 3. pp. 679-682.
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