12-year-old boy with multiple brain masses: Case of month january 2010

Luca Massimi, Massimo Caldarelli, Quintino Giorgio D'Alessandris, Massimo Rollo, Libero Lauriola, Felice Giangaspero, Concezio Di Rocco

Research output: Contribution to journalArticle


The occurrence of more than one brain tumor in a single patient is not new, resulting from RT- or CT-induced neoplasms, syndromes or casual association. We report on the exceptional case of a 12-year-old boy harboring three different brain tumors with no definite correlation. The first MRI showed a medulloblastoma with signs of infratentorial and supratentorial tumor spreading, including a small frontal mass. Despite the good response to surgical and adjuvant treatment, the frontal mass remained unchanged and was excised, revealing a lipoastrocytoma. Finally, the possible local recurrence of the original medulloblastoma was a pilocytic astrocytoma with post-radiation alterations. Explanations of this very unusual association include radio-induced tumors, second tumors developing from remnants of medulloblastoma cancer stem cells, or the changing histology after adjuvant therapy.

Original languageEnglish
Pages (from-to)679-682
Number of pages4
JournalBrain Pathology
Issue number3
Publication statusPublished - May 2010


ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Massimi, L., Caldarelli, M., D'Alessandris, Q. G., Rollo, M., Lauriola, L., Giangaspero, F., & Rocco, C. D. (2010). 12-year-old boy with multiple brain masses: Case of month january 2010. Brain Pathology, 20(3), 679-682. https://doi.org/10.1111/j.1750-3639.2010.00381.x