120 peritoneal carcinomatoses from colorectal cancer treated with peritonectomy and intra-abdominal chemohyperthermia: A S.I.T.I.L.O. multicentric study

Francesco Cavaliere; M. Valle; M. De Simone; M. Deraco; C. R. Rossi; F. Di Filippo; S. Verzi; D. Giannarelli; P. Perri; P. L. Pilati; M. Vaira; S. Di Filippo; A. Garofalo

120 peritoneal carcinomatoses from colorectal cancer treated with peritonectomy and intra-abdominal chemohyperthermia: A S.I.T.I.L.O. multicentric study

Francesco Cavaliere, M. Valle, M. De Simone, M. Deraco, C. R. Rossi, F. Di Filippo, S. Verzi, D. Giannarelli, P. Perri, P. L. Pilati, M. Vaira, S. Di Filippo, A. Garofalo

Research output: Contribution to journal › Article › peer-review

Abstract

A multicentric study has been carried out on 120 patients affected by peritoneal carcinomatosis from colorectal cancer. Patients have been treated by cytoreductive surgery and intra-operative hyperthermic chemoperfusion (HIPEC) with cisplatin (CDDP) and mitomycin-C (MMC). A small group of patients were treated with oxaliplatin (LOHP) following the Elias et al. scheme [intravenous 5- fluorouracil (400 mg/m²) and leucovorin (20 mg/m²) followed by intraperitoneal perfusion with LOHP (460 mg/m²) in 2 l/m², during 30 min at 43°C]. CC-0 cytoreduction was achieved in 85.2% of the patients. Major morbidity and mortality was 22.5% and 3.3%, respectively. No G4 toxicity was registered. The three-year survival was 25.8%. The difference in survival evaluating complete cytoreduction (CC-0) vs. incomplete (CC1-2; residual tumor nodules greater than 2.5 mm) was statistically significant (p

Original language	English
Pages (from-to)	747-750
Number of pages	4
Journal	In Vivo
Volume	20
Issue number	6 A
Publication status	Published - Nov 2006

Keywords

Colorectal cancer
Hyperthermic chemoperfusion
Peritoneal carcinomatosis

ASJC Scopus subject areas

Medicine(all)

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120 peritoneal carcinomatoses from colorectal cancer treated with peritonectomy and intra-abdominal chemohyperthermia : A S.I.T.I.L.O. multicentric study. / Cavaliere, Francesco; Valle, M.; De Simone, M.; Deraco, M.; Rossi, C. R.; Di Filippo, F.; Verzi, S.; Giannarelli, D.; Perri, P.; Pilati, P. L.; Vaira, M.; Di Filippo, S.; Garofalo, A.

In: In Vivo, Vol. 20, No. 6 A, 11.2006, p. 747-750.

Research output: Contribution to journal › Article › peer-review

Cavaliere, Francesco ; Valle, M. ; De Simone, M. ; Deraco, M. ; Rossi, C. R. ; Di Filippo, F. ; Verzi, S. ; Giannarelli, D. ; Perri, P. ; Pilati, P. L. ; Vaira, M. ; Di Filippo, S. ; Garofalo, A. / 120 peritoneal carcinomatoses from colorectal cancer treated with peritonectomy and intra-abdominal chemohyperthermia : A S.I.T.I.L.O. multicentric study. In: In Vivo. 2006 ; Vol. 20, No. 6 A. pp. 747-750.

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abstract = "A multicentric study has been carried out on 120 patients affected by peritoneal carcinomatosis from colorectal cancer. Patients have been treated by cytoreductive surgery and intra-operative hyperthermic chemoperfusion (HIPEC) with cisplatin (CDDP) and mitomycin-C (MMC). A small group of patients were treated with oxaliplatin (LOHP) following the Elias et al. scheme [intravenous 5- fluorouracil (400 mg/m2) and leucovorin (20 mg/m2) followed by intraperitoneal perfusion with LOHP (460 mg/m2) in 2 l/m2, during 30 min at 43°C]. CC-0 cytoreduction was achieved in 85.2% of the patients. Major morbidity and mortality was 22.5% and 3.3%, respectively. No G4 toxicity was registered. The three-year survival was 25.8%. The difference in survival evaluating complete cytoreduction (CC-0) vs. incomplete (CC1-2; residual tumor nodules greater than 2.5 mm) was statistically significant (p",

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AU - Di Filippo, F.

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AU - Garofalo, A.

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