Abstract
A multicentric study has been carried out on 120 patients affected by peritoneal carcinomatosis from colorectal cancer. Patients have been treated by cytoreductive surgery and intra-operative hyperthermic chemoperfusion (HIPEC) with cisplatin (CDDP) and mitomycin-C (MMC). A small group of patients were treated with oxaliplatin (LOHP) following the Elias et al. scheme [intravenous 5- fluorouracil (400 mg/m2) and leucovorin (20 mg/m2) followed by intraperitoneal perfusion with LOHP (460 mg/m2) in 2 l/m2, during 30 min at 43°C]. CC-0 cytoreduction was achieved in 85.2% of the patients. Major morbidity and mortality was 22.5% and 3.3%, respectively. No G4 toxicity was registered. The three-year survival was 25.8%. The difference in survival evaluating complete cytoreduction (CC-0) vs. incomplete (CC1-2; residual tumor nodules greater than 2.5 mm) was statistically significant (p
Original language | English |
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Pages (from-to) | 747-750 |
Number of pages | 4 |
Journal | In Vivo |
Volume | 20 |
Issue number | 6 A |
Publication status | Published - Nov 2006 |
Keywords
- Colorectal cancer
- Hyperthermic chemoperfusion
- Peritoneal carcinomatosis
ASJC Scopus subject areas
- Medicine(all)