120 peritoneal carcinomatoses from colorectal cancer treated with peritonectomy and intra-abdominal chemohyperthermia: A S.I.T.I.L.O. multicentric study

Francesco Cavaliere, M. Valle, M. De Simone, M. Deraco, C. R. Rossi, F. Di Filippo, S. Verzi, D. Giannarelli, P. Perri, P. L. Pilati, M. Vaira, S. Di Filippo, A. Garofalo

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Abstract

A multicentric study has been carried out on 120 patients affected by peritoneal carcinomatosis from colorectal cancer. Patients have been treated by cytoreductive surgery and intra-operative hyperthermic chemoperfusion (HIPEC) with cisplatin (CDDP) and mitomycin-C (MMC). A small group of patients were treated with oxaliplatin (LOHP) following the Elias et al. scheme [intravenous 5- fluorouracil (400 mg/m2) and leucovorin (20 mg/m2) followed by intraperitoneal perfusion with LOHP (460 mg/m2) in 2 l/m2, during 30 min at 43°C]. CC-0 cytoreduction was achieved in 85.2% of the patients. Major morbidity and mortality was 22.5% and 3.3%, respectively. No G4 toxicity was registered. The three-year survival was 25.8%. The difference in survival evaluating complete cytoreduction (CC-0) vs. incomplete (CC1-2; residual tumor nodules greater than 2.5 mm) was statistically significant (p

Original languageEnglish
Pages (from-to)747-750
Number of pages4
JournalIn Vivo
Volume20
Issue number6 A
Publication statusPublished - Nov 2006

Keywords

  • Colorectal cancer
  • Hyperthermic chemoperfusion
  • Peritoneal carcinomatosis

ASJC Scopus subject areas

  • Medicine(all)

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