123I-mIBG scintigraphy in neuroblastoma: development of a SIOPEN semi-quantitative reporting ,method by an international panel.

Val Lewington, Bo Lambert, U. Poetschger, Z. Bar Sever, F. Giammarile, Alexander J B McEwan, Rita Castellani, T. Lynch, Barry L. Shulkin, Mario Drobics, A. Staudenherz, Rudolf Ladenstein

Research output: Contribution to journalArticlepeer-review


PURPOSE: A robust method is required to standardise objective reporting of diagnostic 123I-mIBG images in neuroblastoma. Prerequisites for an appropriate system are low inter- and intra-observer error and reproducibility across a broad disease spectrum. We present a new reporting method, developed and tested for SIOPEN by an international expert panel. METHOD: Patterns of abnormal skeletal
Original languageUndefined/Unknown
Pages (from-to)234-241
Number of pages8
JournalEuropean Journal of Pediatrics
Issue number2
Publication statusPublished - Feb 1 2017


  • *3-Iodobenzylguanidine, *123-meta-iodobenzylguanidine [123I-mIBG], *Imaging, *Neuroblastoma, *Scintigraphy, *SIOPEN-R-NET, *Skeleton, Bone Neoplasms/classification/*diagnostic imaging, Europe, Humans, Image Interpretation, Computer-Assisted/*standards, Internationality, Neuroblastoma/classification/*diagnostic imaging, Observer Variation, Practice Guidelines as Topic, Radiopharmaceuticals, Reproducibility of Results, Sensitivity and Specificity, Tomography, Emission-Computed, Single-Photon/*methods/*standards

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