Abstract
One of the most widely used techniques to support the clinical diagnosis of Parkinsons disease is the SPECT scan with [ 123I]FP-CIT. This tracer binds reversibly and visualizes the striatal presynaptic dopamine transporters. Several uncertainties remain on the value of [ 123I]FP-CIT and SPECT in atypical degenerative parkinsonian syndromes. In this concise review, we discuss the contribution of SPECT and [ 123I]FP-CIT in supporting the clinical diagnosis of Parkinsons disease and their role in the differential diagnosis of Parkinsons disease and atypical degenerative parkinsonism. The chemistry, pharmacodynamics and pharmacokinetics of [ 123I]FP-CIT are also discussed.
Original language | English |
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Pages (from-to) | 411-421 |
Number of pages | 11 |
Journal | Imaging in Medicine |
Volume | 4 |
Issue number | 4 |
DOIs | |
Publication status | Published - Aug 2012 |
Keywords
- atypical degenerative parkinsonism
- FP-CIT
- ioflupane
- SPECT
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology