[ 123I]FP-CIT SPECT in atypical degenerative parkinsonism

Ioannis U. Isaias, Giorgio Marotta, Gianni Pezzoli, Osama Sabri, Swen Hesse

Research output: Contribution to journalArticlepeer-review

Abstract

One of the most widely used techniques to support the clinical diagnosis of Parkinsons disease is the SPECT scan with [ 123I]FP-CIT. This tracer binds reversibly and visualizes the striatal presynaptic dopamine transporters. Several uncertainties remain on the value of [ 123I]FP-CIT and SPECT in atypical degenerative parkinsonian syndromes. In this concise review, we discuss the contribution of SPECT and [ 123I]FP-CIT in supporting the clinical diagnosis of Parkinsons disease and their role in the differential diagnosis of Parkinsons disease and atypical degenerative parkinsonism. The chemistry, pharmacodynamics and pharmacokinetics of [ 123I]FP-CIT are also discussed.

Original languageEnglish
Pages (from-to)411-421
Number of pages11
JournalImaging in Medicine
Volume4
Issue number4
DOIs
Publication statusPublished - Aug 2012

Keywords

  • atypical degenerative parkinsonism
  • FP-CIT
  • ioflupane
  • SPECT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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