1,25-Dihydroxyvitamin D3 upregulates functional CXCR4 human immunodeficiency virus type 1 coreceptors in U937 minus clones: NF-κB- independent enhancement of viral replication

P. Biswas, M. Mengozzi, B. Mantelli, F. Delfanti, A. Brambilla, E. Vicenzi, G. Poli

Research output: Contribution to journalArticlepeer-review

Abstract

U937 cell clones which sustain efficient or poor replication of human immunodeficiency virus type 1 (HIV-1) (referred to herein as plus clones and minus clones, respectively) have been previously described. 1,25- Dihydroxyvitamin D3 (vitamin D3) potently induced HIV-1 replication and proviral DNA accumulation in minus clones but not in plus clones. Vitamin D3 did not induce NF-κB activation but selectively upregulated CXCR4 expression in minus clones. The CXCR4 ligand stromal-cell derived factor-1 induced Ca2+ fluxes and inhibited both constitutive and vitamin D3-enhanced HIV replication in minus clones.

Original languageEnglish
Pages (from-to)8380-8383
Number of pages4
JournalJournal of Virology
Volume72
Issue number10
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of '1,25-Dihydroxyvitamin D3 upregulates functional CXCR4 human immunodeficiency virus type 1 coreceptors in U937 minus clones: NF-κB- independent enhancement of viral replication'. Together they form a unique fingerprint.

Cite this