Abstract
Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion as the sole cytogenetic abnormality (del13q-only) usually have good prognosis, more aggressive clinical courses are documented for del13q-only CLL carrying higher percentages of 13q deleted nuclei. Moreover, deletion at 13q of different sizes have been described, whose prognostic significance is still unknown. In a multi-institutional cohort of 342 del13q-only cases and in a consecutive unselected cohort of 265 CLL, we investigated the prognostic significance of 13q deletion, using the 13q FISH probes locus-specific identifier (LSI)-D13S319 and LSI-RB1 that detect the DLEU2/MIR15A/MIR16-1 and RB1 loci, respectively. Results indicated that both percentage of deleted nuclei and presence of larger deletions involving the RB1 locus cooperated to refine the prognosis of del13q-only cases. In particular, CLL carrying
| Original language | English |
|---|---|
| Pages (from-to) | 633-643 |
| Number of pages | 11 |
| Journal | Genes Chromosomes and Cancer |
| Volume | 50 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2011 |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
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13q14 Deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia. / Dal Bo, Michele; Rossi, Francesca Maria; Rossi, Davide; Deambrogi, Clara; Bertoni, Francesco; Del Giudice, Ilaria; Palumbo, Giuseppe; Nanni, Mauro; Rinaldi, Andrea; Kwee, Ivo; Tissino, Erika; Corradini, Giorgia; Gozzetti, Alessandro; Cencini, Emanuele; Ladetto, Marco; Coletta, Angela Maria; Luciano, Fabrizio; Bulian, Pietro; Pozzato, Gabriele; Laurenti, Luca; Forconi, Francesco; Di Raimondo, Francesco; Marasca, Roberto; Del Poeta, Giovanni; Gaidano, Gianluca; Foà, Robin; Guarini, Anna; Gattei, Valter.
In: Genes Chromosomes and Cancer, Vol. 50, No. 8, 08.2011, p. 633-643.Research output: Contribution to journal › Article
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TY - JOUR
T1 - 13q14 Deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia
AU - Dal Bo, Michele
AU - Rossi, Francesca Maria
AU - Rossi, Davide
AU - Deambrogi, Clara
AU - Bertoni, Francesco
AU - Del Giudice, Ilaria
AU - Palumbo, Giuseppe
AU - Nanni, Mauro
AU - Rinaldi, Andrea
AU - Kwee, Ivo
AU - Tissino, Erika
AU - Corradini, Giorgia
AU - Gozzetti, Alessandro
AU - Cencini, Emanuele
AU - Ladetto, Marco
AU - Coletta, Angela Maria
AU - Luciano, Fabrizio
AU - Bulian, Pietro
AU - Pozzato, Gabriele
AU - Laurenti, Luca
AU - Forconi, Francesco
AU - Di Raimondo, Francesco
AU - Marasca, Roberto
AU - Del Poeta, Giovanni
AU - Gaidano, Gianluca
AU - Foà, Robin
AU - Guarini, Anna
AU - Gattei, Valter
PY - 2011/8
Y1 - 2011/8
N2 - Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion as the sole cytogenetic abnormality (del13q-only) usually have good prognosis, more aggressive clinical courses are documented for del13q-only CLL carrying higher percentages of 13q deleted nuclei. Moreover, deletion at 13q of different sizes have been described, whose prognostic significance is still unknown. In a multi-institutional cohort of 342 del13q-only cases and in a consecutive unselected cohort of 265 CLL, we investigated the prognostic significance of 13q deletion, using the 13q FISH probes locus-specific identifier (LSI)-D13S319 and LSI-RB1 that detect the DLEU2/MIR15A/MIR16-1 and RB1 loci, respectively. Results indicated that both percentage of deleted nuclei and presence of larger deletions involving the RB1 locus cooperated to refine the prognosis of del13q-only cases. In particular, CLL carrying
AB - Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion as the sole cytogenetic abnormality (del13q-only) usually have good prognosis, more aggressive clinical courses are documented for del13q-only CLL carrying higher percentages of 13q deleted nuclei. Moreover, deletion at 13q of different sizes have been described, whose prognostic significance is still unknown. In a multi-institutional cohort of 342 del13q-only cases and in a consecutive unselected cohort of 265 CLL, we investigated the prognostic significance of 13q deletion, using the 13q FISH probes locus-specific identifier (LSI)-D13S319 and LSI-RB1 that detect the DLEU2/MIR15A/MIR16-1 and RB1 loci, respectively. Results indicated that both percentage of deleted nuclei and presence of larger deletions involving the RB1 locus cooperated to refine the prognosis of del13q-only cases. In particular, CLL carrying
UR - http://www.scopus.com/inward/record.url?scp=79958038921&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958038921&partnerID=8YFLogxK
U2 - 10.1002/gcc.20885
DO - 10.1002/gcc.20885
M3 - Article
C2 - 21563234
AN - SCOPUS:79958038921
VL - 50
SP - 633
EP - 643
JO - Genes Chromosomes and Cancer
JF - Genes Chromosomes and Cancer
SN - 1045-2257
IS - 8
ER -