13q14 Deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemia

Michele Dal Bo, Francesca Maria Rossi, Davide Rossi, Clara Deambrogi, Francesco Bertoni, Ilaria Del Giudice, Giuseppe Palumbo, Mauro Nanni, Andrea Rinaldi, Ivo Kwee, Erika Tissino, Giorgia Corradini, Alessandro Gozzetti, Emanuele Cencini, Marco Ladetto, Angela Maria Coletta, Fabrizio Luciano, Pietro Bulian, Gabriele Pozzato, Luca LaurentiFrancesco Forconi, Francesco Di Raimondo, Roberto Marasca, Giovanni Del Poeta, Gianluca Gaidano, Robin Foà, Anna Guarini, Valter Gattei

Research output: Contribution to journalArticlepeer-review


Deletion at 13q14 is detected by fluorescence in situ hybridization (FISH) in about 50% of chronic lymphocytic leukemia (CLL). Although CLL with 13q deletion as the sole cytogenetic abnormality (del13q-only) usually have good prognosis, more aggressive clinical courses are documented for del13q-only CLL carrying higher percentages of 13q deleted nuclei. Moreover, deletion at 13q of different sizes have been described, whose prognostic significance is still unknown. In a multi-institutional cohort of 342 del13q-only cases and in a consecutive unselected cohort of 265 CLL, we investigated the prognostic significance of 13q deletion, using the 13q FISH probes locus-specific identifier (LSI)-D13S319 and LSI-RB1 that detect the DLEU2/MIR15A/MIR16-1 and RB1 loci, respectively. Results indicated that both percentage of deleted nuclei and presence of larger deletions involving the RB1 locus cooperated to refine the prognosis of del13q-only cases. In particular, CLL carrying

Original languageEnglish
Pages (from-to)633-643
Number of pages11
JournalGenes Chromosomes and Cancer
Issue number8
Publication statusPublished - Aug 2011

ASJC Scopus subject areas

  • Cancer Research
  • Genetics


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