14. Cytochemical and ultrastructural study of human glioblastoma cell cultures treated with interleukin-2

M. Civallero, R. Nano, S. Barni, E. Capelli, K. Marinu Aktipi, F. Imbesi, M. Ceroni, G. Giombelli, E. Benericetti

Research output: Contribution to journalArticlepeer-review

Abstract

The interactions between the immune cell system and tumoral cells represent an intriguing problem in the study of tumor biology. In fact at present, many aspects of the immune response against tumors are far to be explained. The effect of the T cell growth factor interleukin-2 on fragments of human glioblastoma cultured in vitro was studied. The proliferation and differentiation of infiltrating leukocytes and of tumoral cells were considered. Light and electron microscopical studies were carried out. In addition a cytochemical analysis using enzyme markers of some cell functions (dihydrofolate reductase, acid phosphatase, dipeptidilaminopeptidase IV, serine esterase BLT-dependent, α-naphtil-acetate-esterase, α-naphtil-butirrate-esterase) was performed. In the presence of interleukin-2 the growth and activation of T lymphocyte subsets and macrophages were observed. The growth of tumoral cell clones induced by recombinant interleukin-2 was also obtained.

Original languageEnglish
Pages (from-to)245
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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