14th International HLA and Immunogenetics Workshop: Report on hematopoietic cell transplantation

Frank Christiansen, Campbell Witt, Peter Bardy, Heather Dunckley, Rhonda Holdsworth, Ian Nicholson, Simon Knowles, Mike Varney, Carmel Kanaan, Mary Diviney, Brian Tait, Gottfried Fischer, Wolfgang Mayr, Thibaut Gervais, Augustin Ferrant, Dominique Latinne, Marie Paule Emonds, Marc A. Boogaerts, Noemi Pereira, Ricardo PasquiniMarlis L. Schroeder, Pavel Jindra, Thomas Karvunidis, Vladimir Koza, Colette Raffoux, Eliane Gluckman, Lena Absi, Dubois Valerie, Jean Denis Bignon, Katia Gagne, Monique Bois, Dominique Charron, Pascale Loiseau, Dominique Masson, Agnes Moine, Anne Dormoy, Martin Bornhauser, Gerhard Ehninger, Monika Füssel, Hans Grosse-Wilde, Domenico Adorno, Paolo Di Bartolomeo, Giovanni Battista Ferrara, Anna Maria Parodi, Miryam Martinetti, Annamaria Pasi, Emilio Paolo Alessandrino, Sonia Nesci, Giuseppe Visani, Yasuo Morishima, Machteld Oudshoorn, Jan J. Cornelissen, Jan Van Rood, Anja Van Biezen, Torstein Egeland, Erik Thorsby, Lorentz Brinch, Ernette DuToit, Peter Jacobs, Mats Bengtsson, Marie Schaffer, Olle Ringdén, Jean Marie Tiercy, Bernand Chapuis, Alois Gratwohl, Urs Schanz, Tsung Dao Lee, Alejandro Madrigal, Steven Marsh, Bronwen Shaw, Mary Horowitz, Michael Haagenson, Stephen Spellman, Katharine Hsu, Effie Petersdorf, Mari Malkki, Gary Schoch, Ted Gooley, David Senitzer, E. Petersdorf, P. Bardy, A. Cambon-Thomsen, E. Goulmy, J. Hansen, A. Schwarer, A. Velardi

Research output: Contribution to journalArticlepeer-review

Abstract

Deciphering the role of human leukocyte antigen (HLA), killer immunoglobulin like receptor, and immune response genes in a model as complex as unrelated donor hematopoietic cell transplantation is a challenge. The allelic diversity of these genes is shaped by the race and ethnicity of transplant donors and recipients. Coupled with the genetic polymorphism is the complexity of clinical phenotypes of transplant populations: donor and recipient demographic characteristics and the regimens used by transplant physicians to prepare patients for transplantation and to prevent and treat graft-vs-host disease (GVHD). Furthermore, GVHD is itself a complex disease shaped by both genes and 'environment'. How does one begin to deconstruct the genetic barrier to understand risk factors important to transplant outcome? To begin with, population-based studies, particularly retrospective ones, benefit from adequate sample sizes to measure genetic effects. The more homogeneous the population for variables that influence clinical endpoints, the higher the likelihood that a real genetic effect can be uncovered. Even so, the feasibility of studies can be hampered if genotype and clinical data are not both complete and precise. For studies of HLA, diversity of alleles and antigens contributed by ethnically different transplant populations is an asset, because not only can a broader range of HLA mismatches be studied but they provide the opportunity for side-by-side analyses that may yield clues as to why transplant outcomes differ between populations.

Original languageEnglish
Pages (from-to)17-24
Number of pages8
JournalTissue Antigens
Volume69
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Apr 2007

Keywords

  • HLA matching
  • Survival
  • Unrelated doner

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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