14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project

M. Ozawa, P. I. Terasaki, J. H. Lee, R. Castro, J. Alberu, C. Alonso, I. Alvarez, R. Toledo, H. Alvez, M. Monterio, J. Teixeira, P. Campbell, M. Ciszek, D. Charron, C. Gautreau, F. Christiansen, R. Conca, B. Gomez, F. Monteon, H. Grosse-WildeF. Heinemann, I. Humar, M. Kamoun, P. Kimball, T. Kobayashi, P. Kupatawintu, S. Leech, W. LeFor, N. Mehra, A. Panigrahi, E. Naumova, D. Norman, A. Piazza, F. Poli, B. Colombo, R. Roy, C. Schonemann, G. Sireci, K. Tanabe, H. Ishida, E. Van Den Berg-Loonen, A. Zeevi

Research output: Contribution to journalArticle

Abstract

An international collaborative study of 45 transplant centers was undertaken at the 14th International HLA (human leukocyte antigen) and Immunogenetics Workshop to see if HLA antibodies detected posttransplant are predictive of chronic graft failure. With the newly developed assay, MICA (major histocompatibility complex class I-related chain A) antibodies were also measured and their effect analyzed. Total of 5219 sera from patients who were more than 6 months posttransplant with functioning graft were tested for HLA antibodies by enzyme-linked immunosorbent assay, flow cytometry, or Luminex. HLA antibodies were found in 27.2% of kidney patients, 23.6% in the liver, 52.7% in the heart, and 21.7% in the lung. The method of antibody testing did not have a marked influence on the frequency of antibodies detected. MICA antibodies were detected in 15% of kidneypatients, 30% of heart patients, and 31% of liver patients. Among 948 kidney patients who had HLA antibodies, 7.3% had rejected their graft within 1 year of testing, compared with 1.7% in 2615 patients without HLA antibodies (P = 0.8 × 10-17). Death occurred in 1.4% of total kidney patients and did not correlate to the presence of antibodies. We conclude that patients with posttransplant HLA antibodies indeed have a higher rate of chronic graft failure and that posttransplant antibodies are predictive of chronic rejection.

Original languageEnglish
Pages (from-to)174-179
Number of pages6
JournalTissue Antigens
Volume69
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Apr 2007

Fingerprint

Immunogenetics
HLA Antigens
Education
Antibodies
Grafts
Transplants
Kidney
Liver
Assays
Immunosorbents
Flow cytometry
Testing
Major Histocompatibility Complex
Flow Cytometry

Keywords

  • Chronic rejection
  • HLA antibody
  • MICA antibody
  • Multi-center study

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Ozawa, M., Terasaki, P. I., Lee, J. H., Castro, R., Alberu, J., Alonso, C., ... Zeevi, A. (2007). 14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project. Tissue Antigens, 69(SUPPL. 1), 174-179. https://doi.org/10.1111/j.1399-0039.2006.00765.x

14th International HLA and Immunogenetics Workshop : Report on the Prospective Chronic Rejection Project. / Ozawa, M.; Terasaki, P. I.; Lee, J. H.; Castro, R.; Alberu, J.; Alonso, C.; Alvarez, I.; Toledo, R.; Alvez, H.; Monterio, M.; Teixeira, J.; Campbell, P.; Ciszek, M.; Charron, D.; Gautreau, C.; Christiansen, F.; Conca, R.; Gomez, B.; Monteon, F.; Grosse-Wilde, H.; Heinemann, F.; Humar, I.; Kamoun, M.; Kimball, P.; Kobayashi, T.; Kupatawintu, P.; Leech, S.; LeFor, W.; Mehra, N.; Panigrahi, A.; Naumova, E.; Norman, D.; Piazza, A.; Poli, F.; Colombo, B.; Roy, R.; Schonemann, C.; Sireci, G.; Tanabe, K.; Ishida, H.; Van Den Berg-Loonen, E.; Zeevi, A.

In: Tissue Antigens, Vol. 69, No. SUPPL. 1, 04.2007, p. 174-179.

Research output: Contribution to journalArticle

Ozawa, M, Terasaki, PI, Lee, JH, Castro, R, Alberu, J, Alonso, C, Alvarez, I, Toledo, R, Alvez, H, Monterio, M, Teixeira, J, Campbell, P, Ciszek, M, Charron, D, Gautreau, C, Christiansen, F, Conca, R, Gomez, B, Monteon, F, Grosse-Wilde, H, Heinemann, F, Humar, I, Kamoun, M, Kimball, P, Kobayashi, T, Kupatawintu, P, Leech, S, LeFor, W, Mehra, N, Panigrahi, A, Naumova, E, Norman, D, Piazza, A, Poli, F, Colombo, B, Roy, R, Schonemann, C, Sireci, G, Tanabe, K, Ishida, H, Van Den Berg-Loonen, E & Zeevi, A 2007, '14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project', Tissue Antigens, vol. 69, no. SUPPL. 1, pp. 174-179. https://doi.org/10.1111/j.1399-0039.2006.00765.x
Ozawa, M. ; Terasaki, P. I. ; Lee, J. H. ; Castro, R. ; Alberu, J. ; Alonso, C. ; Alvarez, I. ; Toledo, R. ; Alvez, H. ; Monterio, M. ; Teixeira, J. ; Campbell, P. ; Ciszek, M. ; Charron, D. ; Gautreau, C. ; Christiansen, F. ; Conca, R. ; Gomez, B. ; Monteon, F. ; Grosse-Wilde, H. ; Heinemann, F. ; Humar, I. ; Kamoun, M. ; Kimball, P. ; Kobayashi, T. ; Kupatawintu, P. ; Leech, S. ; LeFor, W. ; Mehra, N. ; Panigrahi, A. ; Naumova, E. ; Norman, D. ; Piazza, A. ; Poli, F. ; Colombo, B. ; Roy, R. ; Schonemann, C. ; Sireci, G. ; Tanabe, K. ; Ishida, H. ; Van Den Berg-Loonen, E. ; Zeevi, A. / 14th International HLA and Immunogenetics Workshop : Report on the Prospective Chronic Rejection Project. In: Tissue Antigens. 2007 ; Vol. 69, No. SUPPL. 1. pp. 174-179.
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abstract = "An international collaborative study of 45 transplant centers was undertaken at the 14th International HLA (human leukocyte antigen) and Immunogenetics Workshop to see if HLA antibodies detected posttransplant are predictive of chronic graft failure. With the newly developed assay, MICA (major histocompatibility complex class I-related chain A) antibodies were also measured and their effect analyzed. Total of 5219 sera from patients who were more than 6 months posttransplant with functioning graft were tested for HLA antibodies by enzyme-linked immunosorbent assay, flow cytometry, or Luminex. HLA antibodies were found in 27.2{\%} of kidney patients, 23.6{\%} in the liver, 52.7{\%} in the heart, and 21.7{\%} in the lung. The method of antibody testing did not have a marked influence on the frequency of antibodies detected. MICA antibodies were detected in 15{\%} of kidneypatients, 30{\%} of heart patients, and 31{\%} of liver patients. Among 948 kidney patients who had HLA antibodies, 7.3{\%} had rejected their graft within 1 year of testing, compared with 1.7{\%} in 2615 patients without HLA antibodies (P = 0.8 × 10-17). Death occurred in 1.4{\%} of total kidney patients and did not correlate to the presence of antibodies. We conclude that patients with posttransplant HLA antibodies indeed have a higher rate of chronic graft failure and that posttransplant antibodies are predictive of chronic rejection.",
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AU - Lee, J. H.

AU - Castro, R.

AU - Alberu, J.

AU - Alonso, C.

AU - Alvarez, I.

AU - Toledo, R.

AU - Alvez, H.

AU - Monterio, M.

AU - Teixeira, J.

AU - Campbell, P.

AU - Ciszek, M.

AU - Charron, D.

AU - Gautreau, C.

AU - Christiansen, F.

AU - Conca, R.

AU - Gomez, B.

AU - Monteon, F.

AU - Grosse-Wilde, H.

AU - Heinemann, F.

AU - Humar, I.

AU - Kamoun, M.

AU - Kimball, P.

AU - Kobayashi, T.

AU - Kupatawintu, P.

AU - Leech, S.

AU - LeFor, W.

AU - Mehra, N.

AU - Panigrahi, A.

AU - Naumova, E.

AU - Norman, D.

AU - Piazza, A.

AU - Poli, F.

AU - Colombo, B.

AU - Roy, R.

AU - Schonemann, C.

AU - Sireci, G.

AU - Tanabe, K.

AU - Ishida, H.

AU - Van Den Berg-Loonen, E.

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