162 Donne gravide HIV-1 positive e la trasmissione verticale del virus: Risultati di uno studio prospettico

Translated title of the contribution: 162 HIV-1 infected pregnant women and vertical transmission: Results of a prospective study

S. Ferrero, C. Gotta, G. Melica, B. Biasotti, G. Ravera, G. Bentivoglio

Research output: Contribution to journalArticle

Abstract

Background: Aim of this paper is to describe the changes over a 16-year period of the characteristics and management of HIV infected pregnant women. Methods. Prospective study: analysis of data obtained from 162 women and 176 infants. Factors evaluated included: maternal sociodemographic level, immunological and virological parameters, antiretroviral therapy, mode of delivery, pregnancy outcome and babies follow-up. Results. The proportion of women with heterosexual acquisition of infection has increased significantly from 13.5% in 1985-1989 to 47.1% in 1996-2001 (p6/1 (±522.3x106/1). In 1990, 50% of mothers received antiretroviral therapy, rising significantly to 87.5% in 2000. The elective cesarean section was introduced in 1998 and its rate has increased to 75% in 2000. The vertical transmission rate changed from 9.5% in 1985-1989 to 14.3% in 1996-2000 (this difference was not statistically significant, Fisher's exact test). Conclusions. Social characteristics of the HIV-infected women have changed since the mid-1980s: in recent times women are having children at increasingly older ages and are more likely to know that they are HIV infected when they become pregnant. Antiretroviral therapy, elective caesarean delivery and avoidance of breastfeeding can reduce transmission of HIV, but the vertical transmission rate was unaffected by their use in our study and it remains high in comparison with rates reported from other studies.

Translated title of the contribution162 HIV-1 infected pregnant women and vertical transmission: Results of a prospective study
Original languageItalian
Pages (from-to)373-385
Number of pages13
JournalMinerva Ginecologica
Volume54
Issue number5
Publication statusPublished - Oct 2002

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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    Ferrero, S., Gotta, C., Melica, G., Biasotti, B., Ravera, G., & Bentivoglio, G. (2002). 162 Donne gravide HIV-1 positive e la trasmissione verticale del virus: Risultati di uno studio prospettico. Minerva Ginecologica, 54(5), 373-385.