TY - JOUR
T1 - 18-Fluoro-2-deoxyglucose positron emission tomography-computed tomography
T2 - an additional tool in the diagnosis of prosthetic valve endocarditis
AU - Ricciardi, Alessandra
AU - Sordillo, Pasquale
AU - Ceccarelli, Laura
AU - Maffongelli, Gaetano
AU - Calisti, Giorgio
AU - Di Pietro, Barbara
AU - Caracciolo, Cristiana Ragano
AU - Schillaci, Orazio
AU - Pellegrino, Antonio
AU - Chiariello, Luigi
AU - Andreoni, Massimo
AU - Sarmati, Loredana
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Objectives: To evaluate the role of 18-fluoro-2-deoxyglucose positron emission tomography-computed tomography (18F-FDG-PET-CT) in the diagnosis of infectious endocarditis (IE). Methods: We retrospectively examined 27 consecutive patients who were admitted to the Infectious Diseases Department of Tor Vergata University Hospital between 2009 and 2013 with a suspicion of IE. The final IE diagnosis was defined according to the modified Duke criteria, and the microbiological and diagnostic results were collected for each patient. Results: Twenty out of 27 patients had a suspected prosthetic valve endocarditis (PVE) and seven had a suspected native valve endocarditis (NVE). Twenty-five out of 27 patients (92%) had a confirmed diagnosis of IE (18/25 PVE and 7/25 NVE); 16 had a positive echocardiography evaluation and 16 had positive 18F-FDG-PET-CT findings. Echocardiography showed a higher sensitivity as a diagnostic tool for the detection of IE compared to 18F-FDG-PET-CT (80% vs. 55%). However, a greater number of PVE had positive 18F-FDG-PET-CT results compared to those with positive echocardiography findings (11/13 vs. 9/13), and overall 89% (16/18) of confirmed PVE resulted 18F-FDG-PET-CT positive. Analyzing only the cases who underwent transoesophageal echocardiography, 18F-FDG-PET-CT showed a sensitivity of 85% in PVE (vs. 69% for echocardiography and 77% for the Duke criteria). All seven patients with NVE had a positive echocardiography and negative 18F-FDG-PET-CT findings (p18F-FDG-PET-CT in these cases.
AB - Objectives: To evaluate the role of 18-fluoro-2-deoxyglucose positron emission tomography-computed tomography (18F-FDG-PET-CT) in the diagnosis of infectious endocarditis (IE). Methods: We retrospectively examined 27 consecutive patients who were admitted to the Infectious Diseases Department of Tor Vergata University Hospital between 2009 and 2013 with a suspicion of IE. The final IE diagnosis was defined according to the modified Duke criteria, and the microbiological and diagnostic results were collected for each patient. Results: Twenty out of 27 patients had a suspected prosthetic valve endocarditis (PVE) and seven had a suspected native valve endocarditis (NVE). Twenty-five out of 27 patients (92%) had a confirmed diagnosis of IE (18/25 PVE and 7/25 NVE); 16 had a positive echocardiography evaluation and 16 had positive 18F-FDG-PET-CT findings. Echocardiography showed a higher sensitivity as a diagnostic tool for the detection of IE compared to 18F-FDG-PET-CT (80% vs. 55%). However, a greater number of PVE had positive 18F-FDG-PET-CT results compared to those with positive echocardiography findings (11/13 vs. 9/13), and overall 89% (16/18) of confirmed PVE resulted 18F-FDG-PET-CT positive. Analyzing only the cases who underwent transoesophageal echocardiography, 18F-FDG-PET-CT showed a sensitivity of 85% in PVE (vs. 69% for echocardiography and 77% for the Duke criteria). All seven patients with NVE had a positive echocardiography and negative 18F-FDG-PET-CT findings (p18F-FDG-PET-CT in these cases.
KW - F-FDG-PET-CT
KW - Cardiac imaging
KW - Echocardiography
KW - Infective endocarditis
KW - Prosthetic valve endocarditis
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U2 - 10.1016/j.ijid.2014.04.028
DO - 10.1016/j.ijid.2014.04.028
M3 - Article
C2 - 25093540
AN - SCOPUS:84910685658
VL - 28
SP - 219
EP - 224
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
ER -