184. Relationship between haemostatic variables and the progression of carotid atherosclerosis

E. Tremoli, D. Baldassarre, E. Cofrancesco, C. Boschetti, M. Cortellaro

Research output: Contribution to journalArticle

Abstract

Increases in the thickness of common carotid intima-media (CC-IMT), as measured by B-mode ultrasonography, have been widely used in both population studies and clinical trials in the search for risk factors for early atherosclerosis progression. In this study we have investigated the relations between several baseline haemostatic and conventional risk factors and CC-IMT changes over 16 months in 64 peripheral arterial disease (PAD) patients, randomly selected from the prospective PLAT study series. Samples from 24 (37.5%) patients who showed increases in CC-IMT during the followup period were compared with those from 40 (62.5%) in which CC-IMT remained unchanged. Baseline conventional risk factors and coagulation variables were similar in the two groups except for higher plasma concentrations of von Willebrand factor (vWF) (178.3+53.6 vs 141.2±53.7 SD%, p=0.01) and Factor VII (FVII) (133.9±36.4 vs 107.0+27.3, p=0.001) in the patients with increased CC-IMT. CC-IMT increases correlated positively with plasma levels of FVII (r=0.31, p

Original languageEnglish
Pages (from-to)57
Number of pages1
JournalFibrinolysis
Volume10
Issue numberSUPPL. 1
Publication statusPublished - 1996

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Carotid Artery Diseases
Hemostatics
Factor VII
Carotid Intima-Media Thickness
Peripheral Arterial Disease
von Willebrand Factor
Ultrasonography
Atherosclerosis
Clinical Trials
Prospective Studies
Population

ASJC Scopus subject areas

  • Hematology

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184. Relationship between haemostatic variables and the progression of carotid atherosclerosis. / Tremoli, E.; Baldassarre, D.; Cofrancesco, E.; Boschetti, C.; Cortellaro, M.

In: Fibrinolysis, Vol. 10, No. SUPPL. 1, 1996, p. 57.

Research output: Contribution to journalArticle

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