18F-DOPA PET/CT for assessment of response to induction chemotherapy in a child with high-risk neuroblastoma

Arnoldo Piccardo, Egesta Lopci, Luca Foppiani, Giovanni Morana, Massimo Conte

Research output: Contribution to journalArticle

Abstract

Functional imaging plays a crucial role in the assessment of neuroblastoma. The evaluation of response to induction chemotherapy is a cornerstone in scheduling proper treatment management in patients affected by high-risk neuroblastoma. 123I-metaiodobenzylguanidine has been recognized as the radiopharmaceutical of choice in neuroblastoma assessment. To date, the clinical role of PET/CT in pediatric malignancy is not well established. 18F-DOPA-PET/CT has been recently used in neuroblastoma, and compared with 123I-MIBG-scan. Scant new data are available about the role of this tool in the evaluation of treatment response after induction chemotherapy. We investigate the role of 18F-DOPA-PET/CT in characterizing the response to induction chemotherapy in a child affected by high-risk- neuroblastoma, in whom the rare association of 123I-MIBG-negative primary tumor and MIBG-positive bone marrow metastases was observed.

Original languageEnglish
Pages (from-to)355-361
Number of pages7
JournalPediatric Radiology
Volume44
Issue number3
DOIs
Publication statusPublished - 2014

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Keywords

  • Child
  • Neuroblastoma
  • Positron emission tomography/computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pediatrics, Perinatology, and Child Health

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