TY - JOUR
T1 -
18F-DOPA PET/CT in the evaluation of hereditary SDH-deficiency paraganglioma-pheochromocytoma syndromes
AU - Marzola, Maria Cristina
AU - Chondrogiannis, Sotirios
AU - Grassetto, Gaia
AU - Rampin, Lucia
AU - Maffione, Anna Margherita
AU - Ferretti, Alice
AU - Opocher, Giuseppe
AU - Schiavi, Francesca
AU - Colletti, Patrick M.
AU - Rubello, Domenico
PY - 2014/1
Y1 - 2014/1
N2 - PURPOSE: This study aims to evaluate the role of 18F-DOPA PET/CT in staging and follow-up of paraganglioma syndromes succinate dehydrogenase (SDH)-mutation-related patients, comparing 18F-DOPA PET/CT results with morphological imaging and biochemical results. PATIENTS AND METHODS: We retrospectively studied 10 consecutive patients (3 F, 7 M, mean age 32 yrs), all with a genetically demonstrated SDH mutation (5 SDH-D, 4 SDH-B, and 1 SDH-C) and all addressed to 18F-DOPA PET/CT scan. Seven patients had already been operated on for one or more pheochromocytomas and/or paragangliomas and were submitted to 18F-DOPA PET/CT scan according to clinical, biochemical, or radiological suspicion of recurrence, while 3 were only genetically positive, with no previous symptom/sign of the disease. For all patients, biochemical analysis (plasma and/or urinary catecholamine) and results of high-resolution morphological imaging studies (CT and/or MRI) were available. Histologic/cytologic findings or imaging and biochemical follow-up were taken as gold standard in all cases. RESULTS: Seven out of 10 patients showed one or more areas of pathological 18F-DOPA accumulation. PET/CT demonstrated the presence of the disease in 4/6 patients with no increase in catecholamine levels ("biochemically silent"). Positive detection rate was 100% in SDH-D and 40% in "non-SDHD". Analyzing per lesion, 18F-DOPA PET/CT demonstrated more lesions than anatomical imaging (16 vs. 7) especially in head and neck paragangliomas. CONCLUSIONS: 18F-DOPA PET/CT seems to be the more accurate method for staging and restaging patients with SDH-mutations-related paraganglioma syndromes. 18F-DOPA is particularly useful in detecting head and neck and biochemically silent paragangliomas, and also in apparently healthy mutation-carrying people.
AB - PURPOSE: This study aims to evaluate the role of 18F-DOPA PET/CT in staging and follow-up of paraganglioma syndromes succinate dehydrogenase (SDH)-mutation-related patients, comparing 18F-DOPA PET/CT results with morphological imaging and biochemical results. PATIENTS AND METHODS: We retrospectively studied 10 consecutive patients (3 F, 7 M, mean age 32 yrs), all with a genetically demonstrated SDH mutation (5 SDH-D, 4 SDH-B, and 1 SDH-C) and all addressed to 18F-DOPA PET/CT scan. Seven patients had already been operated on for one or more pheochromocytomas and/or paragangliomas and were submitted to 18F-DOPA PET/CT scan according to clinical, biochemical, or radiological suspicion of recurrence, while 3 were only genetically positive, with no previous symptom/sign of the disease. For all patients, biochemical analysis (plasma and/or urinary catecholamine) and results of high-resolution morphological imaging studies (CT and/or MRI) were available. Histologic/cytologic findings or imaging and biochemical follow-up were taken as gold standard in all cases. RESULTS: Seven out of 10 patients showed one or more areas of pathological 18F-DOPA accumulation. PET/CT demonstrated the presence of the disease in 4/6 patients with no increase in catecholamine levels ("biochemically silent"). Positive detection rate was 100% in SDH-D and 40% in "non-SDHD". Analyzing per lesion, 18F-DOPA PET/CT demonstrated more lesions than anatomical imaging (16 vs. 7) especially in head and neck paragangliomas. CONCLUSIONS: 18F-DOPA PET/CT seems to be the more accurate method for staging and restaging patients with SDH-mutations-related paraganglioma syndromes. 18F-DOPA is particularly useful in detecting head and neck and biochemically silent paragangliomas, and also in apparently healthy mutation-carrying people.
KW - F-DOPA PET/CT
KW - Paraganglioma
KW - SDH
KW - Succinate dehydrogenase
UR - http://www.scopus.com/inward/record.url?scp=84891556013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891556013&partnerID=8YFLogxK
U2 - 10.1097/RLU.0b013e31829aface
DO - 10.1097/RLU.0b013e31829aface
M3 - Article
C2 - 23856824
AN - SCOPUS:84891556013
VL - 39
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
SN - 0363-9762
IS - 1
ER -