[18F] FBB cortical uptake is not related to the age of onset of Alzheimer's disease

Agostino Chiaravalloti, Gaetano Barbagallo, Anna Elisa Castellano, Maria Ricci, Gabriele Ciccariello, Francesco Ursini, Nicola D'Ascenzo, Quingguo Xie, Orazio Schillaci

Research output: Contribution to journalArticle

Abstract

AIM: To investigate the relationships between amyloid burden in brain and the age of onset of Alzheimer's disease.

MATERIALS AND METHODS: We examined 60 patients with clinical diagnosis of Alzheimer's disease. Of them, 22 were early-onset of Alzheimer's disease and 38 were late-onset of Alzheimer's disease. All of them underwent a brain PET scan 90 minutes after the injection of 4-[(E)-2-[4-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]phenyl]ethenyl]-N-methylaniline ([F] FBB); 300 ± 10 MBq). Relationships between amyloid burden in brain and age of onset of Alzheimer's disease were assessed by means of statistical parametric mapping version 12.

RESULTS: There were no significant differences [F] FBB uptake between early-onset of Alzheimer's disease and late-onset of Alzheimer's disease patients.

CONCLUSION: In our study group, the age of onset is not related to brain amyloid burden in Alzheimer's disease patients.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalNuclear Medicine Communications
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 2020

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