18F-FDG PET uptake in the pre-Huntington disease caudate affects the time-to-onset independently of CAG expansion size

Andrea Ciarmiello, Giampiero Giovacchini, Sara Orobello, Laura Bruselli, Francesca Elifani, Ferdinando Squitieri

Research output: Contribution to journalArticle

Abstract

Purpose: To test in a longitudinal follow-up study whether basal glucose metabolism in subjects with a genetic risk of Huntington disease (HD) may influence the onset of manifest symptoms. Methods: The study group comprised 43 presymptomatic (preHD) subjects carrying the HD mutation. They underwent a 18F-FDG PET scan and were prospectively followed-up for at least 5 years using the unified HD rating scale to detect clinical changes. Multiple regression analysis included subject's age, CAG mutation size and glucose uptake as variables in a model to predict age at onset. Results: Of the 43 preHD subjects who manifested motor symptoms, suggestive of HD, after 5 years from the PET scan, 26 showed a mean brain glucose uptake below the cut-off of 1.0493 in the caudate, significantly lower than the 17 preHD subjects who remained symptom-free (P

Original languageEnglish
Pages (from-to)1030-1036
Number of pages7
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume39
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • F-FDG PET scan
  • Age at onset prediction
  • Caudate glucose metabolism
  • Phenoconversion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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