18F-fluorodeoxyglucose PET/CT in aplastic anemia: A literature review and the potential of a computational approach

Roberta Piva, Francesco Fiz, Michele Piana, Francesca Bongioanni, Gianluca Bottoni, Andrea Bacigalupo, Cecilia Marini, Gianmario Sambuceti

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: Aplastic anemia (AA) is a rare hematologic condition, characterized by bone marrow (BM) insufficiency, mostly on autoimmune basis. BM inhomogeneity hampers the diagnosis by bioptic sample. We propose a noninvasive evaluation of BM extension and metabolism in different AA stages. Materials & methods: Four AA patients (mean age: 45 ± 21, range: 18-63, 3 females) were submitted to whole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. We compared these patients with matched healthy controls, selected from a published normalcy database. Results: The presence of several hypermetabolic uptake areas was related to BM hypo/aplasia, while homogeneous, low grade FDG uptake was observed in patients in clinical remission. These data suggest that FDG positron emission tomography/computed tomography could be a noninvasive diagnostic complement in AA patients.

Original languageEnglish
Pages (from-to)613-621
Number of pages9
JournalClinical Practice
Volume11
Issue number6
DOIs
Publication statusPublished - Dec 1 2014

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Aplastic Anemia
Fluorodeoxyglucose F18
Bone Marrow
Databases
Positron Emission Tomography Computed Tomography

Keywords

  • aplastic anemia
  • bone marrow
  • FDG
  • hybrid imaging
  • PET/CT

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

Cite this

18F-fluorodeoxyglucose PET/CT in aplastic anemia : A literature review and the potential of a computational approach. / Piva, Roberta; Fiz, Francesco; Piana, Michele; Bongioanni, Francesca; Bottoni, Gianluca; Bacigalupo, Andrea; Marini, Cecilia; Sambuceti, Gianmario.

In: Clinical Practice, Vol. 11, No. 6, 01.12.2014, p. 613-621.

Research output: Contribution to journalArticle

Piva, R, Fiz, F, Piana, M, Bongioanni, F, Bottoni, G, Bacigalupo, A, Marini, C & Sambuceti, G 2014, '18F-fluorodeoxyglucose PET/CT in aplastic anemia: A literature review and the potential of a computational approach', Clinical Practice, vol. 11, no. 6, pp. 613-621. https://doi.org/10.2217/cpr.14.55
Piva, Roberta ; Fiz, Francesco ; Piana, Michele ; Bongioanni, Francesca ; Bottoni, Gianluca ; Bacigalupo, Andrea ; Marini, Cecilia ; Sambuceti, Gianmario. / 18F-fluorodeoxyglucose PET/CT in aplastic anemia : A literature review and the potential of a computational approach. In: Clinical Practice. 2014 ; Vol. 11, No. 6. pp. 613-621.
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