Abstract
Aim: Aplastic anemia (AA) is a rare hematologic condition, characterized by bone marrow (BM) insufficiency, mostly on autoimmune basis. BM inhomogeneity hampers the diagnosis by bioptic sample. We propose a noninvasive evaluation of BM extension and metabolism in different AA stages. Materials & methods: Four AA patients (mean age: 45 ± 21, range: 18-63, 3 females) were submitted to whole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. We compared these patients with matched healthy controls, selected from a published normalcy database. Results: The presence of several hypermetabolic uptake areas was related to BM hypo/aplasia, while homogeneous, low grade FDG uptake was observed in patients in clinical remission. These data suggest that FDG positron emission tomography/computed tomography could be a noninvasive diagnostic complement in AA patients.
| Original language | English |
|---|---|
| Pages (from-to) | 613-621 |
| Number of pages | 9 |
| Journal | Clinical Practice |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Dec 1 2014 |
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Keywords
- aplastic anemia
- bone marrow
- FDG
- hybrid imaging
- PET/CT
ASJC Scopus subject areas
- Medicine(all)
- Pharmacology (medical)
Cite this
18F-fluorodeoxyglucose PET/CT in aplastic anemia : A literature review and the potential of a computational approach. / Piva, Roberta; Fiz, Francesco; Piana, Michele; Bongioanni, Francesca; Bottoni, Gianluca; Bacigalupo, Andrea; Marini, Cecilia; Sambuceti, Gianmario.
In: Clinical Practice, Vol. 11, No. 6, 01.12.2014, p. 613-621.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 18F-fluorodeoxyglucose PET/CT in aplastic anemia
T2 - A literature review and the potential of a computational approach
AU - Piva, Roberta
AU - Fiz, Francesco
AU - Piana, Michele
AU - Bongioanni, Francesca
AU - Bottoni, Gianluca
AU - Bacigalupo, Andrea
AU - Marini, Cecilia
AU - Sambuceti, Gianmario
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Aim: Aplastic anemia (AA) is a rare hematologic condition, characterized by bone marrow (BM) insufficiency, mostly on autoimmune basis. BM inhomogeneity hampers the diagnosis by bioptic sample. We propose a noninvasive evaluation of BM extension and metabolism in different AA stages. Materials & methods: Four AA patients (mean age: 45 ± 21, range: 18-63, 3 females) were submitted to whole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. We compared these patients with matched healthy controls, selected from a published normalcy database. Results: The presence of several hypermetabolic uptake areas was related to BM hypo/aplasia, while homogeneous, low grade FDG uptake was observed in patients in clinical remission. These data suggest that FDG positron emission tomography/computed tomography could be a noninvasive diagnostic complement in AA patients.
AB - Aim: Aplastic anemia (AA) is a rare hematologic condition, characterized by bone marrow (BM) insufficiency, mostly on autoimmune basis. BM inhomogeneity hampers the diagnosis by bioptic sample. We propose a noninvasive evaluation of BM extension and metabolism in different AA stages. Materials & methods: Four AA patients (mean age: 45 ± 21, range: 18-63, 3 females) were submitted to whole-body 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. We compared these patients with matched healthy controls, selected from a published normalcy database. Results: The presence of several hypermetabolic uptake areas was related to BM hypo/aplasia, while homogeneous, low grade FDG uptake was observed in patients in clinical remission. These data suggest that FDG positron emission tomography/computed tomography could be a noninvasive diagnostic complement in AA patients.
KW - aplastic anemia
KW - bone marrow
KW - FDG
KW - hybrid imaging
KW - PET/CT
UR - http://www.scopus.com/inward/record.url?scp=84920077417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920077417&partnerID=8YFLogxK
U2 - 10.2217/cpr.14.55
DO - 10.2217/cpr.14.55
M3 - Article
AN - SCOPUS:84920077417
VL - 11
SP - 613
EP - 621
JO - Clinical Practice
JF - Clinical Practice
SN - 2044-9038
IS - 6
ER -