18FDG-PET e vasculiti dei grandi vasi: Studio preliminare su 25 pazienti

Translated title of the contribution: 18FDG-PET and large vessel vasculitis: Preliminary data on 25 patients

Marco Bruschi, F. De Leonardis, M. Govoni, M. Roncali, N. Prandini, R. La Corte, L. Feggi, F. Trotta

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the predictive value of clinical and biochemical features when compared to 18FDG-PET in the diagnostic work-up of large vessel vasculitis (LVV). Methods: Twenty-five patients underwent 18FDG-PET for the clinical suspect of LVV. All of them presented history of systemic symptoms lasting ≥6 months and laboratoristic evidence of persistently high markers of inflammation. The patients were stratified according with: i) clinical manifestations, defined as presence of one or more ACR criteria for the classification of LVV; ii) laboratory investigations: Erythrocyte Sedimentation Rate (ESR) higher or lower than 50 mm/h, C-Reactive Protein (CRP) higher or lower than 2 mg/dl; iii) prednisone dose in the 4 weeks preceding PET examination. Results: The total number of positive PET was higher in the group without clinical ACR criteria and in the group with inflammation markers under the established cut-off. The number of scans consistent with LVV was higher in the groups presenting one or more clinical criteria for LVV but in those with very high ESR and CRP. In all the cases differences between groups were not statistically significative. A clear cut negative correlation between steroid dose and number of scans suggestive for LVV has been observed. Conclusions: Diagnosis of LVV remains challenging, especially in patients presenting with a constellation of non-specific symptoms and laboratory findings. In this study, both clinical and biochemical features show low correlation with a vasculitic pattern of FDG uptake. In our experience 18FDG-PET represents an useful diagnostic tool in early stages of LVV and a powerful instrument to follow the treatment responses.

Original languageItalian
Pages (from-to)212-216
Number of pages5
JournalReumatismo
Volume60
Issue number3
Publication statusPublished - 2008

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Fluorodeoxyglucose F18
Vasculitis
Blood Sedimentation
C-Reactive Protein
Inflammation
Prednisone
Steroids

ASJC Scopus subject areas

  • Rheumatology

Cite this

Bruschi, M., De Leonardis, F., Govoni, M., Roncali, M., Prandini, N., La Corte, R., ... Trotta, F. (2008). 18FDG-PET e vasculiti dei grandi vasi: Studio preliminare su 25 pazienti. Reumatismo, 60(3), 212-216.

18FDG-PET e vasculiti dei grandi vasi : Studio preliminare su 25 pazienti. / Bruschi, Marco; De Leonardis, F.; Govoni, M.; Roncali, M.; Prandini, N.; La Corte, R.; Feggi, L.; Trotta, F.

In: Reumatismo, Vol. 60, No. 3, 2008, p. 212-216.

Research output: Contribution to journalArticle

Bruschi, M, De Leonardis, F, Govoni, M, Roncali, M, Prandini, N, La Corte, R, Feggi, L & Trotta, F 2008, '18FDG-PET e vasculiti dei grandi vasi: Studio preliminare su 25 pazienti', Reumatismo, vol. 60, no. 3, pp. 212-216.
Bruschi M, De Leonardis F, Govoni M, Roncali M, Prandini N, La Corte R et al. 18FDG-PET e vasculiti dei grandi vasi: Studio preliminare su 25 pazienti. Reumatismo. 2008;60(3):212-216.
Bruschi, Marco ; De Leonardis, F. ; Govoni, M. ; Roncali, M. ; Prandini, N. ; La Corte, R. ; Feggi, L. ; Trotta, F. / 18FDG-PET e vasculiti dei grandi vasi : Studio preliminare su 25 pazienti. In: Reumatismo. 2008 ; Vol. 60, No. 3. pp. 212-216.
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AB - Objective: To evaluate the predictive value of clinical and biochemical features when compared to 18FDG-PET in the diagnostic work-up of large vessel vasculitis (LVV). Methods: Twenty-five patients underwent 18FDG-PET for the clinical suspect of LVV. All of them presented history of systemic symptoms lasting ≥6 months and laboratoristic evidence of persistently high markers of inflammation. The patients were stratified according with: i) clinical manifestations, defined as presence of one or more ACR criteria for the classification of LVV; ii) laboratory investigations: Erythrocyte Sedimentation Rate (ESR) higher or lower than 50 mm/h, C-Reactive Protein (CRP) higher or lower than 2 mg/dl; iii) prednisone dose in the 4 weeks preceding PET examination. Results: The total number of positive PET was higher in the group without clinical ACR criteria and in the group with inflammation markers under the established cut-off. The number of scans consistent with LVV was higher in the groups presenting one or more clinical criteria for LVV but in those with very high ESR and CRP. In all the cases differences between groups were not statistically significative. A clear cut negative correlation between steroid dose and number of scans suggestive for LVV has been observed. Conclusions: Diagnosis of LVV remains challenging, especially in patients presenting with a constellation of non-specific symptoms and laboratory findings. In this study, both clinical and biochemical features show low correlation with a vasculitic pattern of FDG uptake. In our experience 18FDG-PET represents an useful diagnostic tool in early stages of LVV and a powerful instrument to follow the treatment responses.

KW - FDG-PET

KW - Giant cell arteritis

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