[18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment

D. Perani; C. Colombo; S. Bressi; A. Bonfanti; F. Grassi; S. Scarone; L. Bellodi; E. Smeraldi; F. Fazio

[18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment

D. Perani, C. Colombo, S. Bressi, A. Bonfanti, F. Grassi, S. Scarone, L. Bellodi, E. Smeraldi, F. Fazio

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Background. We used [¹⁸F]FDG and PET in patients with obsessive-compulsive disorder (OCD) to evaluate cerebral metabolic involvement before and after treatment with serotonin-specific reuptake inhibitors. Method. In 11 untreated, drug-free adults, regional cerebral metabolic rate for glucose (rCMRglu) was compared with that of 15 age-matched normal controls. Results. rCMRglu values were significantly increased in the cingulate cortex, thalamus and pallidum/putamen complex. After treatment a significant improvement in obsessive-compulsive symptoms on the Y-BOC scale (t=3.59, P

Original language	English
Pages (from-to)	244-250
Number of pages	7
Journal	British Journal of Psychiatry
Volume	166
Issue number	FEB.
Publication status	Published - 1995

ASJC Scopus subject areas

Psychiatry and Mental health
Neuroscience(all)

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abstract = "Background. We used [18F]FDG and PET in patients with obsessive-compulsive disorder (OCD) to evaluate cerebral metabolic involvement before and after treatment with serotonin-specific reuptake inhibitors. Method. In 11 untreated, drug-free adults, regional cerebral metabolic rate for glucose (rCMRglu) was compared with that of 15 age-matched normal controls. Results. rCMRglu values were significantly increased in the cingulate cortex, thalamus and pallidum/putamen complex. After treatment a significant improvement in obsessive-compulsive symptoms on the Y-BOC scale (t=3.59, P",

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T1 - [18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment

AU - Perani, D.

AU - Colombo, C.

AU - Bressi, S.

AU - Bonfanti, A.

AU - Grassi, F.

AU - Scarone, S.

AU - Bellodi, L.

AU - Smeraldi, E.

AU - Fazio, F.

PY - 1995

Y1 - 1995

N2 - Background. We used [18F]FDG and PET in patients with obsessive-compulsive disorder (OCD) to evaluate cerebral metabolic involvement before and after treatment with serotonin-specific reuptake inhibitors. Method. In 11 untreated, drug-free adults, regional cerebral metabolic rate for glucose (rCMRglu) was compared with that of 15 age-matched normal controls. Results. rCMRglu values were significantly increased in the cingulate cortex, thalamus and pallidum/putamen complex. After treatment a significant improvement in obsessive-compulsive symptoms on the Y-BOC scale (t=3.59, P

AB - Background. We used [18F]FDG and PET in patients with obsessive-compulsive disorder (OCD) to evaluate cerebral metabolic involvement before and after treatment with serotonin-specific reuptake inhibitors. Method. In 11 untreated, drug-free adults, regional cerebral metabolic rate for glucose (rCMRglu) was compared with that of 15 age-matched normal controls. Results. rCMRglu values were significantly increased in the cingulate cortex, thalamus and pallidum/putamen complex. After treatment a significant improvement in obsessive-compulsive symptoms on the Y-BOC scale (t=3.59, P

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[18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment

Abstract

ASJC Scopus subject areas

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