[18F]FDG PET study in obsessive-compulsive disorder. A clinical/metabolic correlation study after treatment

D. Perani, C. Colombo, S. Bressi, A. Bonfanti, F. Grassi, S. Scarone, L. Bellodi, E. Smeraldi, F. Fazio

Research output: Contribution to journalArticlepeer-review

Abstract

Background. We used [18F]FDG and PET in patients with obsessive-compulsive disorder (OCD) to evaluate cerebral metabolic involvement before and after treatment with serotonin-specific reuptake inhibitors. Method. In 11 untreated, drug-free adults, regional cerebral metabolic rate for glucose (rCMRglu) was compared with that of 15 age-matched normal controls. Results. rCMRglu values were significantly increased in the cingulate cortex, thalamus and pallidum/putamen complex. After treatment a significant improvement in obsessive-compulsive symptoms on the Y-BOC scale (t=3.59, P

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalBritish Journal of Psychiatry
Volume166
Issue numberFEB.
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

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