18f‐fdg pet/ct cannot substitute endoscopy in the staging of gastrointestinal involvement in mantle cell lymphoma. A retrospective multi‐center cohort analysis

Tetiana Skrypets, Cristina Ferrari, Luca Nassi, Gloria Margiottacasaluci, Benedetta Puccini, Lara Mannelli, Kateryna Filonenko, Irina Kryachok, Felice Clemente, Maria Carmela Vegliante, Antonella Daniele, Gianmauro Sacchetti, Attilio Guarini, Carla Minoia

Research output: Contribution to journalArticlepeer-review

Abstract

The detection of gastrointestinal (GI) involvement in Mantle Cell Lymphoma is often underestimated and may have an impact on outcome and clinical management. We aimed to evaluate whether baseline 18F‐FDG PET/CT presents comparable results to endoscopic biopsy in the diagnosis of GI localizations. In our retrospective cohort of 79 patients, sensitivity and specificity of 18F‐FDG PET/CT were low for the stomach, with a fair concordance (k = 0.32), while higher concordance with pathologic results (k = 0.65) was detected in the colorectal tract. Thus, gastric biopsy remains helpful in the staging of MCL despite 18F‐FDG PET/CT, while colonoscopy could be omitted in asymptomatic patients. The validation of our data in prospective cohorts is desirable.

Original languageEnglish
Article number123
Pages (from-to)1-10
Number of pages10
JournalJournal of Personalized Medicine
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 2021

Keywords

  • 18F‐FDG PET/CT
  • Colorectal biopsy
  • Endoscopy
  • Gastric biopsy
  • Mantle Cell Lymphoma
  • Staging

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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