[18F]FDG positron emission tomography/computed tomography and multidetector computed tomography roles in thymic lesion treatment planning

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11 Citations (Scopus)

Abstract

Rationale: Thymic masses may represent an unsolved diagnostic problem which often require surgical procedures for an accurate staging. A non-invasive way to determine the nature of thymic lesions would help identify the patients which are true candidates for surgery. Our retrospective study aims to assess multidetector computed tomography and 2-[18F]fluoro-2-deoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) capacity to distinguish benign from malignant thymic lesions. Methods: Helical multidetector CT (MDCT) and [18F]FDG-PET/CT of twenty consecutive patients presenting with a thymic mass at our Institute were retrospectively analyzed. MDCT scans were focused on morphologic features and invasiveness characteristics. Qualitative and semi-quantitative analyses by maximum standardized uptake value corrected for body weight (SUVbw max) were performed on [18F]FDG-PET/CT. In all cases, readers were blinded to pathology findings. Both imaging techniques were correlated to final pathology. Student's t-test was performed on SUVbw max stratified for thymic epithelial tumors. Results: In the group of benign lesions MDCT correctly identified well-defined margins of masses in 8 out of 8 patients whereas [18F]FDG-PET/CT was negative in 7 out of 8 patients. Among malignant lesions MDCT revealed mediastinum fat or infiltration of adjacent organs in 10/12 patients. On the other hand [18F]FDG-PET/CT showed increased radiotracer uptake in 12/12 patients. Conclusions: MDCT and [18F]FDG-PET/CT alone are not able to differentiate the nature of thymic lesions. However, they are two non-invasive complementary techniques which can be used to differentiate benign from high-risk malignant thymic lesions. These findings should be taken into account before surgery is performed as a diagnostic procedure.

Original languageEnglish
Pages (from-to)362-368
Number of pages7
JournalLung Cancer
Volume61
Issue number3
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Multidetector Computed Tomography
Fluorodeoxyglucose F18
Therapeutics
Pathology
Spiral Computed Tomography
Mediastinum
Positron Emission Tomography Computed Tomography
Retrospective Studies
Fats
Body Weight
Students

Keywords

  • Benign thymic lesions
  • Epithelial thymic lesions
  • Fluorodeoxyglucose
  • Multidetector CT
  • PET/CT
  • SUV

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

@article{0369a87920e745198af4d5f0b895b2c7,
title = "[18F]FDG positron emission tomography/computed tomography and multidetector computed tomography roles in thymic lesion treatment planning",
abstract = "Rationale: Thymic masses may represent an unsolved diagnostic problem which often require surgical procedures for an accurate staging. A non-invasive way to determine the nature of thymic lesions would help identify the patients which are true candidates for surgery. Our retrospective study aims to assess multidetector computed tomography and 2-[18F]fluoro-2-deoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) capacity to distinguish benign from malignant thymic lesions. Methods: Helical multidetector CT (MDCT) and [18F]FDG-PET/CT of twenty consecutive patients presenting with a thymic mass at our Institute were retrospectively analyzed. MDCT scans were focused on morphologic features and invasiveness characteristics. Qualitative and semi-quantitative analyses by maximum standardized uptake value corrected for body weight (SUVbw max) were performed on [18F]FDG-PET/CT. In all cases, readers were blinded to pathology findings. Both imaging techniques were correlated to final pathology. Student's t-test was performed on SUVbw max stratified for thymic epithelial tumors. Results: In the group of benign lesions MDCT correctly identified well-defined margins of masses in 8 out of 8 patients whereas [18F]FDG-PET/CT was negative in 7 out of 8 patients. Among malignant lesions MDCT revealed mediastinum fat or infiltration of adjacent organs in 10/12 patients. On the other hand [18F]FDG-PET/CT showed increased radiotracer uptake in 12/12 patients. Conclusions: MDCT and [18F]FDG-PET/CT alone are not able to differentiate the nature of thymic lesions. However, they are two non-invasive complementary techniques which can be used to differentiate benign from high-risk malignant thymic lesions. These findings should be taken into account before surgery is performed as a diagnostic procedure.",
keywords = "Benign thymic lesions, Epithelial thymic lesions, Fluorodeoxyglucose, Multidetector CT, PET/CT, SUV",
author = "Travaini, {Laura L.} and Giuseppe Petralia and Giuseppe Trifir{\`o} and Laura Ravasi and Domenico Galetta and Giuseppe Carbone and Fabio Falcini and Lorenzo Spaggiari and Massimo Bellomi and Giovanni Paganelli",
year = "2008",
month = "9",
doi = "10.1016/j.lungcan.2008.01.019",
language = "English",
volume = "61",
pages = "362--368",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - [18F]FDG positron emission tomography/computed tomography and multidetector computed tomography roles in thymic lesion treatment planning

AU - Travaini, Laura L.

AU - Petralia, Giuseppe

AU - Trifirò, Giuseppe

AU - Ravasi, Laura

AU - Galetta, Domenico

AU - Carbone, Giuseppe

AU - Falcini, Fabio

AU - Spaggiari, Lorenzo

AU - Bellomi, Massimo

AU - Paganelli, Giovanni

PY - 2008/9

Y1 - 2008/9

N2 - Rationale: Thymic masses may represent an unsolved diagnostic problem which often require surgical procedures for an accurate staging. A non-invasive way to determine the nature of thymic lesions would help identify the patients which are true candidates for surgery. Our retrospective study aims to assess multidetector computed tomography and 2-[18F]fluoro-2-deoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) capacity to distinguish benign from malignant thymic lesions. Methods: Helical multidetector CT (MDCT) and [18F]FDG-PET/CT of twenty consecutive patients presenting with a thymic mass at our Institute were retrospectively analyzed. MDCT scans were focused on morphologic features and invasiveness characteristics. Qualitative and semi-quantitative analyses by maximum standardized uptake value corrected for body weight (SUVbw max) were performed on [18F]FDG-PET/CT. In all cases, readers were blinded to pathology findings. Both imaging techniques were correlated to final pathology. Student's t-test was performed on SUVbw max stratified for thymic epithelial tumors. Results: In the group of benign lesions MDCT correctly identified well-defined margins of masses in 8 out of 8 patients whereas [18F]FDG-PET/CT was negative in 7 out of 8 patients. Among malignant lesions MDCT revealed mediastinum fat or infiltration of adjacent organs in 10/12 patients. On the other hand [18F]FDG-PET/CT showed increased radiotracer uptake in 12/12 patients. Conclusions: MDCT and [18F]FDG-PET/CT alone are not able to differentiate the nature of thymic lesions. However, they are two non-invasive complementary techniques which can be used to differentiate benign from high-risk malignant thymic lesions. These findings should be taken into account before surgery is performed as a diagnostic procedure.

AB - Rationale: Thymic masses may represent an unsolved diagnostic problem which often require surgical procedures for an accurate staging. A non-invasive way to determine the nature of thymic lesions would help identify the patients which are true candidates for surgery. Our retrospective study aims to assess multidetector computed tomography and 2-[18F]fluoro-2-deoxyglucose positron emission tomography/computed tomography ([18F]FDG-PET/CT) capacity to distinguish benign from malignant thymic lesions. Methods: Helical multidetector CT (MDCT) and [18F]FDG-PET/CT of twenty consecutive patients presenting with a thymic mass at our Institute were retrospectively analyzed. MDCT scans were focused on morphologic features and invasiveness characteristics. Qualitative and semi-quantitative analyses by maximum standardized uptake value corrected for body weight (SUVbw max) were performed on [18F]FDG-PET/CT. In all cases, readers were blinded to pathology findings. Both imaging techniques were correlated to final pathology. Student's t-test was performed on SUVbw max stratified for thymic epithelial tumors. Results: In the group of benign lesions MDCT correctly identified well-defined margins of masses in 8 out of 8 patients whereas [18F]FDG-PET/CT was negative in 7 out of 8 patients. Among malignant lesions MDCT revealed mediastinum fat or infiltration of adjacent organs in 10/12 patients. On the other hand [18F]FDG-PET/CT showed increased radiotracer uptake in 12/12 patients. Conclusions: MDCT and [18F]FDG-PET/CT alone are not able to differentiate the nature of thymic lesions. However, they are two non-invasive complementary techniques which can be used to differentiate benign from high-risk malignant thymic lesions. These findings should be taken into account before surgery is performed as a diagnostic procedure.

KW - Benign thymic lesions

KW - Epithelial thymic lesions

KW - Fluorodeoxyglucose

KW - Multidetector CT

KW - PET/CT

KW - SUV

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