[18F]FDG synthesis by Anatech RB-86 robotic system

Improvements and general considerations

A. Bogni, C. Pascali, R. Iwata, A. Cavalleri, V. De Sanctis, D. Decise, G. Cucchetti, F. Crippa, C. Chiesa, M. Schiavini, E. Bombardieri

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A series of changes and updatings to the [18F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [18O]H2O recovery, 'one-pot' reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume230
Issue number1-2
DOIs
Publication statusPublished - 1998

Fingerprint

Fluorodeoxyglucose F18
Robotics
Hydrolysis
Recovery

ASJC Scopus subject areas

  • Analytical Chemistry
  • Inorganic Chemistry
  • Nuclear Energy and Engineering

Cite this

[18F]FDG synthesis by Anatech RB-86 robotic system : Improvements and general considerations. / Bogni, A.; Pascali, C.; Iwata, R.; Cavalleri, A.; De Sanctis, V.; Decise, D.; Cucchetti, G.; Crippa, F.; Chiesa, C.; Schiavini, M.; Bombardieri, E.

In: Journal of Radioanalytical and Nuclear Chemistry, Vol. 230, No. 1-2, 1998, p. 45-50.

Research output: Contribution to journalArticle

Bogni, A. ; Pascali, C. ; Iwata, R. ; Cavalleri, A. ; De Sanctis, V. ; Decise, D. ; Cucchetti, G. ; Crippa, F. ; Chiesa, C. ; Schiavini, M. ; Bombardieri, E. / [18F]FDG synthesis by Anatech RB-86 robotic system : Improvements and general considerations. In: Journal of Radioanalytical and Nuclear Chemistry. 1998 ; Vol. 230, No. 1-2. pp. 45-50.
@article{cdbcd85f1db84873ab2683d8fb8cefb0,
title = "[18F]FDG synthesis by Anatech RB-86 robotic system: Improvements and general considerations",
abstract = "A series of changes and updatings to the [18F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [18O]H2O recovery, 'one-pot' reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81{\%} (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.",
author = "A. Bogni and C. Pascali and R. Iwata and A. Cavalleri and {De Sanctis}, V. and D. Decise and G. Cucchetti and F. Crippa and C. Chiesa and M. Schiavini and E. Bombardieri",
year = "1998",
doi = "10.1007/BF02387445",
language = "English",
volume = "230",
pages = "45--50",
journal = "Journal of Radioanalytical Chemistry",
issn = "0022-4081",
publisher = "Springer Netherlands",
number = "1-2",

}

TY - JOUR

T1 - [18F]FDG synthesis by Anatech RB-86 robotic system

T2 - Improvements and general considerations

AU - Bogni, A.

AU - Pascali, C.

AU - Iwata, R.

AU - Cavalleri, A.

AU - De Sanctis, V.

AU - Decise, D.

AU - Cucchetti, G.

AU - Crippa, F.

AU - Chiesa, C.

AU - Schiavini, M.

AU - Bombardieri, E.

PY - 1998

Y1 - 1998

N2 - A series of changes and updatings to the [18F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [18O]H2O recovery, 'one-pot' reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.

AB - A series of changes and updatings to the [18F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [18O]H2O recovery, 'one-pot' reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.

UR - http://www.scopus.com/inward/record.url?scp=0031918227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031918227&partnerID=8YFLogxK

U2 - 10.1007/BF02387445

DO - 10.1007/BF02387445

M3 - Article

VL - 230

SP - 45

EP - 50

JO - Journal of Radioanalytical Chemistry

JF - Journal of Radioanalytical Chemistry

SN - 0022-4081

IS - 1-2

ER -