[18F]FDG synthesis by Anatech RB-86 robotic system: Improvements and general considerations

A. Bogni, C. Pascali, R. Iwata, A. Cavalleri, V. De Sanctis, D. Decise, G. Cucchetti, F. Crippa, C. Chiesa, M. Schiavini, E. Bombardieri

Research output: Contribution to journalArticle

Abstract

A series of changes and updatings to the [18F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [18O]H2O recovery, 'one-pot' reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume230
Issue number1-2
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Analytical Chemistry
  • Inorganic Chemistry
  • Nuclear Energy and Engineering

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    Bogni, A., Pascali, C., Iwata, R., Cavalleri, A., De Sanctis, V., Decise, D., Cucchetti, G., Crippa, F., Chiesa, C., Schiavini, M., & Bombardieri, E. (1998). [18F]FDG synthesis by Anatech RB-86 robotic system: Improvements and general considerations. Journal of Radioanalytical and Nuclear Chemistry, 230(1-2), 45-50. https://doi.org/10.1007/BF02387445