2-3 difosfoglicerato ed ossigenazione tissutale nel cirrotico.

Translated title of the contribution: 2-3 diphosphoglycerate and tissue oxygenation in the cirrhotic

G. Vendemiale, E. Altomare, N. Stufano, V. Procacci, O. Albano

Research output: Contribution to journalArticlepeer-review


Increased 2-3 Diphosphoglycerate levels in cirrhotic patients have been reported. Previous studies did not show significant changes in 2-3 DPG in anaemic cirrhotic patients when compared to non anaemic cirrhotic patients, but the role played by alkalosis and/or hypoxia has not been investigated. To study this question, haematic 2-3 DPG was measured in 8 male patients with liver cirrhosis (histologically diagnosed) together with PO2, PCO2, pH and Hct. 2-3 DPG was also measured in 6 healthy male volunteers. We found a significant increase in blood 2-3 DPG of cirrhotic patients compared to control subjects (5,55 +/- 0,4 vs 2,18 +/- 0,3 mmol/l erythrocytes respectively, p less than 0,001) in agreement with previous studies. PO2 levels and Hct value did not show important changes, whereas PCO2 and pH resulted to be very altered when compared to normal values, even though we could not correlate these values with blood 2-3 DPG. We conclude that the genesis of 2-3 DPG increase is multifactorial, however an alteration in acid-base equilibrium seems to play a more important role than hypoxia.

Translated title of the contribution2-3 diphosphoglycerate and tissue oxygenation in the cirrhotic
Original languageItalian
Pages (from-to)107-112
Number of pages6
JournalBollettino della Societa Italiana di Biologia Sperimentale
Issue number1
Publication statusPublished - Jan 30 1985

ASJC Scopus subject areas

  • Medicine(all)


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