2-{4-[3-(4-Aryl/heteroaryl-1-piperazinyl)propoxy]phenyl}-2H-benzotriaz-oles and their N-oxides as ligands for serotonin and dopamine receptors

Anna Sparatore, Mara Goegan, Alfredo Cagnotto, Fabio Sparatore

Research output: Contribution to journalArticle

Abstract

A small set of 2-{4-[3-(4-aryl/heteroaryl-piperazinyl)propoxy]phenyl}-2H-benzotriazoles and corresponding N-oxides were prepared. The synthesized compounds were able to bind on some serotonin (5-HT(1A), 5-HT(2A)) and dopamine (D2, D3) receptors, while displaying poor or no affinity for 5-HT(1B), 5-HT(2C), 5-HT3, and 5-HT4 subtypes. The strong contribution of the N-oxide function for the binding on 5-HT(1A), D2 and D3 receptors is noteworthy. For 2-{4-[3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy]phenyl}-2H-benzotriazol-1 -oxide (4b), the binding constants (K(i)) were 11.9 (5-HT(1A)) and 10.5 nM (D3). In a general pharmacological screening, the 2-(4-[3-(4-phenyl-1-piperazinyl)propoxy]phenyl}-2H-benzotriazole (3a) exhibited only very weak activities, with the exception of protecting mice from cyanide-induced hypoxia.

Original languageEnglish
Pages (from-to)402-410
Number of pages9
JournalFarmaco
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 30 1999

Keywords

  • Benzotriazole-N-oxides
  • Benzotriazoles
  • Dopamine receptor ligands
  • Serotonin receptor ligands

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmaceutical Science

Fingerprint Dive into the research topics of '2-{4-[3-(4-Aryl/heteroaryl-1-piperazinyl)propoxy]phenyl}-2H-benzotriaz-oles and their N-oxides as ligands for serotonin and dopamine receptors'. Together they form a unique fingerprint.

  • Cite this