2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

Marc P. Baggelaar, Mauro Maccarrone, Mario van der Stelt

Research output: Contribution to journalReview article

Abstract

2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid. Finally, we discuss the potential therapeutic benefits of modulating 2-AG levels in the brain.

Original languageEnglish
Pages (from-to)1-17
Number of pages17
JournalProgress in Lipid Research
Volume71
DOIs
Publication statusPublished - Jul 1 2018

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

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