TY - JOUR
T1 - 2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido) benzamides
T2 - Synthesis, antiproliferativeactivity, and mechanism of action
AU - Raffa, Demetrio
AU - Maggio, Benedetta
AU - Raimondi, Maria Valeria
AU - Cusimano, Maria Grazia
AU - Amico, Giandomenico
AU - Carollo, Anna
AU - Conaldi, Pier Giulio
AU - Bai, Ruoli
AU - Hamel, Ernest
AU - Daidone, Giuseppe
PY - 2013
Y1 - 2013
N2 - Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).
AB - Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).
KW - 2-(3-Phenylpropanamido)benzamides
KW - 2-(3-Phenylpropiolamido)benzamides
KW - 2-Cinnamamidobenzamides
KW - Antiproliferative activity
KW - Apoptosis
UR - http://www.scopus.com/inward/record.url?scp=84878725211&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878725211&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2013.04.068
DO - 10.1016/j.ejmech.2013.04.068
M3 - Article
C2 - 23747810
AN - SCOPUS:84878725211
VL - 65
SP - 427
EP - 435
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
SN - 0223-5234
ER -