2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido) benzamides: Synthesis, antiproliferativeactivity, and mechanism of action

Demetrio Raffa; Benedetta Maggio; Maria Valeria Raimondi; Maria Grazia Cusimano; Giandomenico Amico; Anna Carollo; Pier Giulio Conaldi; Ruoli Bai; Ernest Hamel; Giuseppe Daidone

doi:10.1016/j.ejmech.2013.04.068

2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido) benzamides: Synthesis, antiproliferativeactivity, and mechanism of action

Demetrio Raffa, Benedetta Maggio, Maria Valeria Raimondi, Maria Grazia Cusimano, Giandomenico Amico, Anna Carollo, Pier Giulio Conaldi, Ruoli Bai, Ernest Hamel, Giuseppe Daidone

ISMETT

Research output: Contribution to journal › Article › peer-review

Abstract

Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

Original language	English
Pages (from-to)	427-435
Number of pages	9
Journal	European Journal of Medicinal Chemistry
Volume	65
DOIs	https://doi.org/10.1016/j.ejmech.2013.04.068
Publication status	Published - 2013

Keywords

2-(3-Phenylpropanamido)benzamides
2-(3-Phenylpropiolamido)benzamides
2-Cinnamamidobenzamides
Antiproliferative activity
Apoptosis

ASJC Scopus subject areas

Drug Discovery
Organic Chemistry
Pharmacology

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Raffa, D., Maggio, B., Raimondi, M. V., Cusimano, M. G., Amico, G., Carollo, A., Conaldi, P. G., Bai, R., Hamel, E., & Daidone, G. (2013). 2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido) benzamides: Synthesis, antiproliferativeactivity, and mechanism of action. European Journal of Medicinal Chemistry, 65, 427-435. https://doi.org/10.1016/j.ejmech.2013.04.068

2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido) benzamides : Synthesis, antiproliferativeactivity, and mechanism of action. / Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Amico, Giandomenico; Carollo, Anna; Conaldi, Pier Giulio; Bai, Ruoli; Hamel, Ernest; Daidone, Giuseppe.

In: European Journal of Medicinal Chemistry, Vol. 65, 2013, p. 427-435.

Research output: Contribution to journal › Article › peer-review

Raffa, D, Maggio, B, Raimondi, MV, Cusimano, MG, Amico, G, Carollo, A, Conaldi, PG, Bai, R, Hamel, E & Daidone, G 2013, '2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido) benzamides: Synthesis, antiproliferativeactivity, and mechanism of action', European Journal of Medicinal Chemistry, vol. 65, pp. 427-435. https://doi.org/10.1016/j.ejmech.2013.04.068

Raffa, Demetrio ; Maggio, Benedetta ; Raimondi, Maria Valeria ; Cusimano, Maria Grazia ; Amico, Giandomenico ; Carollo, Anna ; Conaldi, Pier Giulio ; Bai, Ruoli ; Hamel, Ernest ; Daidone, Giuseppe. / 2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido) benzamides : Synthesis, antiproliferativeactivity, and mechanism of action. In: European Journal of Medicinal Chemistry. 2013 ; Vol. 65. pp. 427-435.

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abstract = "Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).",

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