2-Cinnamamido, 2-(3-phenylpropiolamido), and 2-(3-phenylpropanamido) benzamides: Synthesis, antiproliferativeactivity, and mechanism of action

Demetrio Raffa, Benedetta Maggio, Maria Valeria Raimondi, Maria Grazia Cusimano, Giandomenico Amico, Anna Carollo, Pier Giulio Conaldi, Ruoli Bai, Ernest Hamel, Giuseppe Daidone

Research output: Contribution to journalArticlepeer-review

Abstract

Several new benzamides 4a-q were synthesized by stirring in pyridine the acid chlorides 3a-q with the appropriate anthranilamide derivatives 2a-g. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

Original languageEnglish
Pages (from-to)427-435
Number of pages9
JournalEuropean Journal of Medicinal Chemistry
Volume65
DOIs
Publication statusPublished - 2013

Keywords

  • 2-(3-Phenylpropanamido)benzamides
  • 2-(3-Phenylpropiolamido)benzamides
  • 2-Cinnamamidobenzamides
  • Antiproliferative activity
  • Apoptosis

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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