2-Litre polyethylene glycol-citrate-simethicone plus bisacodyl versus 4-litre polyethylene glycol as preparation for colonoscopy in chronic constipation

Fabrizio Parente, Cristian Vailati, Stefano Bargiggia, Gianpiero Manes, Paola Fontana, Enzo Masci, Monica Arena, Giancarlo Spinzi, Alessandra Baccarin, Giorgia Mazzoleni, Pier Alberto Testoni

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Chronic constipation is a risk factor of inadequate bowel preparation for colonoscopy; however, no large clinical trials have been performed in this subgroup of patients. Aims: To compare bowel cleansing efficacy, tolerability and acceptability of 2-L polyethylene-glycol-citrate-simethicone (PEG-CS) plus 2-day bisacodyl (reinforced regimen) vs. 4-L PEG in patients with chronic constipation undergoing colonoscopy. Methods: Randomized, observer-blind, parallel group study. Adult outpatients undergoing colonoscopy were randomly allocated to 2-L PEG-CS/bisacodyl or 4-L PEG, taken as split regimens before colonoscopy. Quality of bowel preparation was assessed by the Ottawa Bowel Cleansing Scale (OBCS). The amount of foam/bubble interfering with colonic visualization was also measured. Results: 400 patients were enrolled. There was no significant difference in successful cleansing (OBCS score ≤6): 80.2% in the 2-L PEG-CS/bisacodyl vs. 81.4% in the 4-L PEG group. Significantly more patients taking 2L PEG-CS/bisacodyl showed no or minimal foam/bubbles in all colonic segments (80% vs. 63%; p

Original languageEnglish
Pages (from-to)857-863
Number of pages7
JournalDigestive and Liver Disease
Volume47
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • Bisacodyl
  • Bowel preparation for colonoscopy
  • Chronic constipation
  • Low volume bowel preparation
  • Ottawa Bowel Cleansing Scale
  • Polyethylene glycol
  • Simethicone
  • Split-dose

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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