2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

M. Rondy, O. Launay, J. Puig-Barberà, G. Gefenaite, J. Castilla, K. de Gaetano Donati, F. Galtier, E. Hak, M. Guevara, S. Costanzo, A. Moren, Nezha Lenzi, Zineb Lesieur, Isabelle Bonmarin, Xavier Duval, Yolande Costa, Annuxcy Kanagaratnam, Yazdan Yazdapanah, Marion Caseris, Nathalie DournonThomas Papo, Antoine Dossier, Hakim Bécheur, Anne Laure Pelletier, Hervé Mal, Armelle Marceau, Michel Aubier, Raphaêl Bories, Enrique Casalino, Christophe Choquet, Nadhira Houhou, Pierre Loulergue, Reem Kanaan, Florence Dumas, Déborah Postil, Sébastien Alcoléa, Sylvie Rogez, Philippe Vanhaems, Corinne Régis, Corinne Merle, Vincent Foulongne, Marine Ray, Véronique Maugueret-Doublet, Arnaud Bourdin, Liliane Landreau, Amadou Konaté, Philippe Corne, Mustapha Sebbane, Kada Klouche, Marie Suzanne Léglise, Martine Valette, Bruno Lina, Fabrice Carrat, Frédéric Chau, Javier Díez-Domingo, Begoña Escribano-López, Alberto Arnedo-Pena, Montserrat Ruiz-García, Miguel Tortajada-Girbés, Consuelo Carratalá Munuera, Julio Barrenengoa Sañudo, Rosa Larrea-González, Vicente Gil-Guillén, German Schwarz-Chavarri, Janette Rahamat-Langendoen, Hubert Niesters, Arvydas Ambrozaitis, Ligita Jancoriene, Aukse Mickiene, Monika Kuliese, Daiva Velyvyte, Ronald P. Stolk, Kestutis Zagminas, Carmen Ezpeleta, Judith Chamorro, Pilar Artajo, Francisco Lameiro, Ana Navascués, Maite Ortega, Montse Torres, José Javier García Irure, Fátima Irisarri, Manuel García Cenoz, Iván Martínez-Baz, Roberto Cauda, Concetta Donato, Rosaria Santangelo, Francesco Perlasca, Giovanni Fichera, Marianna Dara, Licia Iacoviello, Marco Olivieri

Research output: Contribution to journalArticle

Abstract

While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.

Original languageEnglish
Article number21011
JournalEuro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin
Volume20
Issue number2
Publication statusPublished - Jan 15 2015

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Influenza Vaccines
Human Influenza
Health Services Needs and Demand
Confidence Intervals
Orthomyxoviridae
Lithuania
Spain
Italy
Reverse Transcription
France
Logistic Models
Polymerase Chain Reaction
Incidence

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Virology

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2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B : estimates from a European network of hospitals. / Rondy, M.; Launay, O.; Puig-Barberà, J.; Gefenaite, G.; Castilla, J.; de Gaetano Donati, K.; Galtier, F.; Hak, E.; Guevara, M.; Costanzo, S.; Moren, A.; Lenzi, Nezha; Lesieur, Zineb; Bonmarin, Isabelle; Duval, Xavier; Costa, Yolande; Kanagaratnam, Annuxcy; Yazdapanah, Yazdan; Caseris, Marion; Dournon, Nathalie; Papo, Thomas; Dossier, Antoine; Bécheur, Hakim; Pelletier, Anne Laure; Mal, Hervé; Marceau, Armelle; Aubier, Michel; Bories, Raphaêl; Casalino, Enrique; Choquet, Christophe; Houhou, Nadhira; Loulergue, Pierre; Kanaan, Reem; Dumas, Florence; Postil, Déborah; Alcoléa, Sébastien; Rogez, Sylvie; Vanhaems, Philippe; Régis, Corinne; Merle, Corinne; Foulongne, Vincent; Ray, Marine; Maugueret-Doublet, Véronique; Bourdin, Arnaud; Landreau, Liliane; Konaté, Amadou; Corne, Philippe; Sebbane, Mustapha; Klouche, Kada; Léglise, Marie Suzanne; Valette, Martine; Lina, Bruno; Carrat, Fabrice; Chau, Frédéric; Díez-Domingo, Javier; Escribano-López, Begoña; Arnedo-Pena, Alberto; Ruiz-García, Montserrat; Tortajada-Girbés, Miguel; Munuera, Consuelo Carratalá; Sañudo, Julio Barrenengoa; Larrea-González, Rosa; Gil-Guillén, Vicente; Schwarz-Chavarri, German; Rahamat-Langendoen, Janette; Niesters, Hubert; Ambrozaitis, Arvydas; Jancoriene, Ligita; Mickiene, Aukse; Kuliese, Monika; Velyvyte, Daiva; Stolk, Ronald P.; Zagminas, Kestutis; Ezpeleta, Carmen; Chamorro, Judith; Artajo, Pilar; Lameiro, Francisco; Navascués, Ana; Ortega, Maite; Torres, Montse; Irure, José Javier García; Irisarri, Fátima; Cenoz, Manuel García; Martínez-Baz, Iván; Cauda, Roberto; Donato, Concetta; Santangelo, Rosaria; Perlasca, Francesco; Fichera, Giovanni; Dara, Marianna; Iacoviello, Licia; Olivieri, Marco.

In: Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin, Vol. 20, No. 2, 21011, 15.01.2015.

Research output: Contribution to journalArticle

Rondy, M, Launay, O, Puig-Barberà, J, Gefenaite, G, Castilla, J, de Gaetano Donati, K, Galtier, F, Hak, E, Guevara, M, Costanzo, S, Moren, A, Lenzi, N, Lesieur, Z, Bonmarin, I, Duval, X, Costa, Y, Kanagaratnam, A, Yazdapanah, Y, Caseris, M, Dournon, N, Papo, T, Dossier, A, Bécheur, H, Pelletier, AL, Mal, H, Marceau, A, Aubier, M, Bories, R, Casalino, E, Choquet, C, Houhou, N, Loulergue, P, Kanaan, R, Dumas, F, Postil, D, Alcoléa, S, Rogez, S, Vanhaems, P, Régis, C, Merle, C, Foulongne, V, Ray, M, Maugueret-Doublet, V, Bourdin, A, Landreau, L, Konaté, A, Corne, P, Sebbane, M, Klouche, K, Léglise, MS, Valette, M, Lina, B, Carrat, F, Chau, F, Díez-Domingo, J, Escribano-López, B, Arnedo-Pena, A, Ruiz-García, M, Tortajada-Girbés, M, Munuera, CC, Sañudo, JB, Larrea-González, R, Gil-Guillén, V, Schwarz-Chavarri, G, Rahamat-Langendoen, J, Niesters, H, Ambrozaitis, A, Jancoriene, L, Mickiene, A, Kuliese, M, Velyvyte, D, Stolk, RP, Zagminas, K, Ezpeleta, C, Chamorro, J, Artajo, P, Lameiro, F, Navascués, A, Ortega, M, Torres, M, Irure, JJG, Irisarri, F, Cenoz, MG, Martínez-Baz, I, Cauda, R, Donato, C, Santangelo, R, Perlasca, F, Fichera, G, Dara, M, Iacoviello, L & Olivieri, M 2015, '2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals', Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin, vol. 20, no. 2, 21011.
Rondy, M. ; Launay, O. ; Puig-Barberà, J. ; Gefenaite, G. ; Castilla, J. ; de Gaetano Donati, K. ; Galtier, F. ; Hak, E. ; Guevara, M. ; Costanzo, S. ; Moren, A. ; Lenzi, Nezha ; Lesieur, Zineb ; Bonmarin, Isabelle ; Duval, Xavier ; Costa, Yolande ; Kanagaratnam, Annuxcy ; Yazdapanah, Yazdan ; Caseris, Marion ; Dournon, Nathalie ; Papo, Thomas ; Dossier, Antoine ; Bécheur, Hakim ; Pelletier, Anne Laure ; Mal, Hervé ; Marceau, Armelle ; Aubier, Michel ; Bories, Raphaêl ; Casalino, Enrique ; Choquet, Christophe ; Houhou, Nadhira ; Loulergue, Pierre ; Kanaan, Reem ; Dumas, Florence ; Postil, Déborah ; Alcoléa, Sébastien ; Rogez, Sylvie ; Vanhaems, Philippe ; Régis, Corinne ; Merle, Corinne ; Foulongne, Vincent ; Ray, Marine ; Maugueret-Doublet, Véronique ; Bourdin, Arnaud ; Landreau, Liliane ; Konaté, Amadou ; Corne, Philippe ; Sebbane, Mustapha ; Klouche, Kada ; Léglise, Marie Suzanne ; Valette, Martine ; Lina, Bruno ; Carrat, Fabrice ; Chau, Frédéric ; Díez-Domingo, Javier ; Escribano-López, Begoña ; Arnedo-Pena, Alberto ; Ruiz-García, Montserrat ; Tortajada-Girbés, Miguel ; Munuera, Consuelo Carratalá ; Sañudo, Julio Barrenengoa ; Larrea-González, Rosa ; Gil-Guillén, Vicente ; Schwarz-Chavarri, German ; Rahamat-Langendoen, Janette ; Niesters, Hubert ; Ambrozaitis, Arvydas ; Jancoriene, Ligita ; Mickiene, Aukse ; Kuliese, Monika ; Velyvyte, Daiva ; Stolk, Ronald P. ; Zagminas, Kestutis ; Ezpeleta, Carmen ; Chamorro, Judith ; Artajo, Pilar ; Lameiro, Francisco ; Navascués, Ana ; Ortega, Maite ; Torres, Montse ; Irure, José Javier García ; Irisarri, Fátima ; Cenoz, Manuel García ; Martínez-Baz, Iván ; Cauda, Roberto ; Donato, Concetta ; Santangelo, Rosaria ; Perlasca, Francesco ; Fichera, Giovanni ; Dara, Marianna ; Iacoviello, Licia ; Olivieri, Marco. / 2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B : estimates from a European network of hospitals. In: Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin. 2015 ; Vol. 20, No. 2.
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abstract = "While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3{\%} (95{\%} confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8{\%} (95{\%} CI: 26.8 to 80.0; n=557) and 43.1{\%} (95{\%} CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.",
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TY - JOUR

T1 - 2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B

T2 - estimates from a European network of hospitals

AU - Rondy, M.

AU - Launay, O.

AU - Puig-Barberà, J.

AU - Gefenaite, G.

AU - Castilla, J.

AU - de Gaetano Donati, K.

AU - Galtier, F.

AU - Hak, E.

AU - Guevara, M.

AU - Costanzo, S.

AU - Moren, A.

AU - Lenzi, Nezha

AU - Lesieur, Zineb

AU - Bonmarin, Isabelle

AU - Duval, Xavier

AU - Costa, Yolande

AU - Kanagaratnam, Annuxcy

AU - Yazdapanah, Yazdan

AU - Caseris, Marion

AU - Dournon, Nathalie

AU - Papo, Thomas

AU - Dossier, Antoine

AU - Bécheur, Hakim

AU - Pelletier, Anne Laure

AU - Mal, Hervé

AU - Marceau, Armelle

AU - Aubier, Michel

AU - Bories, Raphaêl

AU - Casalino, Enrique

AU - Choquet, Christophe

AU - Houhou, Nadhira

AU - Loulergue, Pierre

AU - Kanaan, Reem

AU - Dumas, Florence

AU - Postil, Déborah

AU - Alcoléa, Sébastien

AU - Rogez, Sylvie

AU - Vanhaems, Philippe

AU - Régis, Corinne

AU - Merle, Corinne

AU - Foulongne, Vincent

AU - Ray, Marine

AU - Maugueret-Doublet, Véronique

AU - Bourdin, Arnaud

AU - Landreau, Liliane

AU - Konaté, Amadou

AU - Corne, Philippe

AU - Sebbane, Mustapha

AU - Klouche, Kada

AU - Léglise, Marie Suzanne

AU - Valette, Martine

AU - Lina, Bruno

AU - Carrat, Fabrice

AU - Chau, Frédéric

AU - Díez-Domingo, Javier

AU - Escribano-López, Begoña

AU - Arnedo-Pena, Alberto

AU - Ruiz-García, Montserrat

AU - Tortajada-Girbés, Miguel

AU - Munuera, Consuelo Carratalá

AU - Sañudo, Julio Barrenengoa

AU - Larrea-González, Rosa

AU - Gil-Guillén, Vicente

AU - Schwarz-Chavarri, German

AU - Rahamat-Langendoen, Janette

AU - Niesters, Hubert

AU - Ambrozaitis, Arvydas

AU - Jancoriene, Ligita

AU - Mickiene, Aukse

AU - Kuliese, Monika

AU - Velyvyte, Daiva

AU - Stolk, Ronald P.

AU - Zagminas, Kestutis

AU - Ezpeleta, Carmen

AU - Chamorro, Judith

AU - Artajo, Pilar

AU - Lameiro, Francisco

AU - Navascués, Ana

AU - Ortega, Maite

AU - Torres, Montse

AU - Irure, José Javier García

AU - Irisarri, Fátima

AU - Cenoz, Manuel García

AU - Martínez-Baz, Iván

AU - Cauda, Roberto

AU - Donato, Concetta

AU - Santangelo, Rosaria

AU - Perlasca, Francesco

AU - Fichera, Giovanni

AU - Dara, Marianna

AU - Iacoviello, Licia

AU - Olivieri, Marco

PY - 2015/1/15

Y1 - 2015/1/15

N2 - While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.

AB - While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case–control study to estimate IVE against hospitalised laboratoryconfirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged ≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1) pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1) pdm09.

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M3 - Article

C2 - 25613779

AN - SCOPUS:84926507200

VL - 20

JO - Eurosurveillance

JF - Eurosurveillance

SN - 1560-7917

IS - 2

M1 - 21011

ER -